Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us +44 1223 790975

GET THE APP

Early Brain Connectivity Alterations Before Amyloid Deposition In A Rat Model Of Alzheimers Disease | 99433
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Early brain connectivity alterations before amyloid deposition in a rat model of Alzheimers disease

12th International Conference on Alzheimer's Disease & Dementia

Guadalupe Soria

Institut d Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Spain

ScientificTracks Abstracts: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460-C7-054

Abstract
Animal models of Alzheimer???s disease (AD) are essential in understanding the disease progression and development of early biomarkers. In this study, a transgenic rat model of AD (TgF344-AD) was longitudinally analyzed to describe both cognitive performance and brain connectivity. Cognitive abilities were assessed longitudinally by a delayed non match-tosample (DNMS). Every three months after DNMS, MRI acquisition was performed including diffusion-weighted MRI and resting state functional MRI, which were processed to obtain the structural and functional connectomes, respectively. Global and regional graph metrics were computed to evaluate network organization in both transgenic and control rats. Less efficient organization of the structural brain networks of the transgenic rats with respect to controls was observed at five months of age, before a significant concentration of ?-amyloid plaques is present. Specific regional differences in connectivity were identified in both structural and functional networks. A strong correlation was observed between cognitive performance and brain networks, including whole brain structural connectivity as well as functional and structural network metrics of regions related to reward, memory and sensory performance processes. Despite, the fact that the Tg animals showed a smaller number of responses in the first phase, the hit rate was very similar in both groups throughout the study. The AD also is a connectopathy in the TgF344AD rat model and this integrative approach is without a doubt, a track that promises results much more efficient from the point of view of translational research.
Biography

Guadalupe Soria is Incharge of the Experimental MRI 7T Unit at IDIBAPS, Barcelona. She has specialization studying Neurodegeneration, MRI Biomarkers and Animal Models. Her areas of research interests are discovery of MRI biomarkers for early diagnosis of neurodegenerative disorders such as AD, shortening of the translational gap between preclinical and clinical research and cognitive enhancement as a potential intervention for AD.

E-mail: guadalupe.soria@idibaps.org

 

https://bahigox.fun/ https://bahisjet.fun/ https://bahsegel.fun/ https://betboo.fun/ https://betdoksan.xyz/ https://betebetgiris.xyz/ https://betexper.fun/ https://betgram.fun/ https://betkanyon.fun/ https://betkolik.fun/
Top