alexa Early Brain Network Alterations Are Correlated With ?-CTF In Alzheimer?s Transgenic Mouse Model
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Alzheimers Disease and Dementia
September 23-25, 2014 Valencia Convention Centre, Spain

Siddhartha Mondragon Rodriguez, Ning Gu, Richard Boyce, Frederic Manseau and Sylvain Williams
Posters: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.009
Abstract
Alzheimer?s disease is defined by the presence of amyloid-? (A?) and tau protein aggregates. However, increasing data is suggesting that earlier phenomena such as brain network alterations rather that protein deposition could account for the pathogenesis of the disease. Here we found that earlier fragments of A? processing rather than plaque deposits are critically associated to abnormal function of brain networks. By measuring brain protein alterations in the hippocampus of Alzheimer?s J20 transgenic mouse model at four weeks of age, we found significant increases in ?-CTF, a protein precursor to A? peptides. In addition, the ?-CTF increase was found to be directly correlated with hippocampal circuit malfunction at this age. By performing extracellular field recording method at the subiculum region in vitro, we found reduced theta-gamma cross-frequency coupling at low (25-45 Hz) and high (150-250 Hz) gamma range. Interestingly, despite these network changes, the J20 mice did not present cognitive deficit at this age. In summary, our data suggests that brain network alterations precede the canonical A? protein deposition. In addition, we found that circuit alterations may be caused by ?-CTF, suggesting that early pharmacological prevention of brain circuit alterations might represent a more promising strategy towards delaying the development of Alzheimer?s disease.
Biography
Siddhartha Mondragon Rodriguez graduated in Chemical Engineering from Michoacan University of Saint Nicolas of Hidalgo (UMICH) in 1996 - 2002. Master Degree (MsC) in Molecular Biomedicine from National School of Medicine from the National Polytechnic Institute of Mexico City. PhD from Center of Research and Advanced Studies of the National Politechnical Institute in August 2005 - August 2009. PosdoctoralFellow from Universite de Montreal. Faculte de Medecine, Departament de physiologie., Montreal, Qc, Canada. Posdoctoral Position in McGill University.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords