alexa Effect Of Ginger (Zingiber Officinale) On Alzheimer?s Disease Induced In Rats | 22026
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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2nd International Conference on Alzheimers Disease and Dementia

Karam A Mahdy, Nadia A M Gouda, Abd El-Fattah H Marrie, Nemat A Z Yassin, Siham M A El-Shenawy, Abdel Razik H Farrag and Bassant M M Ibrahim
Accepted Abstracts: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.010
Abstract
Background/Aim: Alzheimer?s disease (AD) is a progressive neurodegenerative disorder characterized by an increased oxidative stress. Ginger is a medicinal plant with antioxidant activities. The present study aim to investigate the effect of Ginger in Alzheimer?s disease induced in rats. Materials and Methods: 90 Male rats were classified into 9 groups as follows: control group, AD protective group using AlCl3, 3rd, 4th, and 5th groups rats were received orally Rivastigmine, Ginger (108 and 216 mg/kg/day) respectively, for two weeks followed by combination of each treatment for another 4 weeks. 6th group is a therapeutic AD group, while 7th, 8th & 9th groups are AD rats treated with the same doses of Rivastigmine and Ginger daily for 12 successive weeks. At baseline and after each treatment, behavioral stress tests, Rotarod and T-Maze tests were done. At the end of all experiments rats? brains were dissected and prepared for determination of acetylcholine (Ach), acetycholinesterase (AchE) levels and histopathologic examination. Results: This study indicated that AD-induced rats exhibited reduction in the activity, decreased ability to maintain balance on the Rotaroad and significant delay in T-Maze test, significant reduction in brain Ach and increase AchE levels. While rats treated with Rivastigmine and Ginger in protective and therapeutic groups exhibited significant improvement in behavior, Rotarod and T-Maze, significant increase in brain Ach and decrease AchE levels. These results were consistent with the histopathological findings in brains. Conclusion: This study revealed that the treatment of AD-induced rats with Rivastagmine, and Ginger significantly ameliorates the neurodegeneration characteristic of Alzheimer?s diseases in rats.
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