Journal of Gastrointestinal & Digestive System
Open Access

Abstract

Introduction: Ziziphus jujuba stem bark is used in Iranian traditional medicine as a treatment of many diseases specially, gastrointestinal disease and wound healing. Based on traditional books, the present investigation evaluated the gastro protective effects of standardized aqueous extracts of Z. jujuba stem bark against acidified ethanol-induced gastric ulcers as well as antihelicobacter pylori activity of the plant extract. Materials & Methods: Five groups of rats were orally pre-treated with normal saline (0.9%) as ulcer group, 150 mg/kg of ranitidine as positive group, 100 mg, 200 mg and 400 mg of standardized extract solution as the experimental groups, respectively. Two hours later, acidified ethanol solution was given orally in order to induction of gastric ulcer. Antibacterial against clinical strains of H. pylori evaluated through disc diffusion method. Results: Ulcer group exhibited significantly severe mucosal injury as compared with ranitidine or extract which shows significant protection towards gastric mucosal injury the plant promotes ulcer protection as it shows significant reduction of ulcer area, and histology showed marked reduction of edema in mucosal and submucosal layer compared with ulcer group. Z. jujuba stem bark extract had no effects against on H. pylori. Conclusion: The present study indicates that Z. jujuba stem bark extract have potential antiulcer activity which might be due to its anti-secretory activity and increased resistance to necrotizing agents, providing a direct, protective effect on the gastric mucosa. Our study showed that anti- H. pylori activity is not among gastroprotective mechanism of Z. jujuba. Further preclinical and clinical investigation for evaluating natural active agents and efficacy of this plant is recommended.

Biography

Email: HamediSH1@mums.ac.ir