alexa Gallic Acid Prevents Memory Deficits And Oxidative Stress Induced By Intra-cerebroventricular Injection Of Streptozotocin In Rats
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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2nd International Conference on Alzheimers Disease and Dementia
September 23-25, 2014 Valencia Convention Centre, Spain

Mohammad Taghi Mansouri, Bahareh Naghizadeh, Behnam Ghorbanzadeh, Yaghoub Farbood, Alireza Sarkaki and Kowsar Bavarsad
Accepted Abstracts: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.010
Abstract
In the present study, we evaluated the effects of gallic acid (GA; 30 mg/kg, orally, once daily for 26 days starting from day 5 prior to streptozotocin injection) on cognitive impairment and cerebral oxidative stress induced by intracerebroventricularstreptozotocin (ICV-STZ; bilaterally, two doses of 3 mg/kg) injection as an animal model of sporadic Alzheimers type (SDAT) in rats. The results showed that ICV-STZ-injection reduced the passive avoidance and spatial memory performance associated with decreased non-enzymatic [total thiol concentration, -58.5%, -50.7%] and enzymatic [superoxide dismutase (SOD, -30.2%, -32.9%), catalase (CAT, 43.5%, 50.7%), glutathione peroxidase (GPx, 57.1%, 61.7%)] activities and increased the level of thiobarbituric acid reactive species (TBARS, +103.5%, +82.5%) in the hippocampus and cerebral cortex, respectively. In contrast, chronic administration of GA significantly prevented cognitive deficits and biochemical alterations in the ICV-STZ rats. These findings highlight the beneficial role of GA in the ICV-STZ rats via enhancement of cerebral antioxidant defense system. Thus, it may have a therapeutic value for the treatment of SDAT.
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