Granulocyte Colony Stimulating Factor (G-CSF) Protects Intestinal Injury And Increases Survival Rate In Irradiated Mice | 3495
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 1384

Journal of Gastrointestinal & Digestive System received 1384 citations as per Google Scholar report

Journal of Gastrointestinal & Digestive System peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Granulocyte colony stimulating factor (G-CSF) protects intestinal injury and increases survival rate in irradiated mice

2nd International Conference on Gastroenterology & Urology

Joong Sun Kim

Posters: J Gastrointest Dig Syst

DOI: 10.4172/2161-069X.S1.018

Granulocyte colony stimulating factor (G-CSF) has been reported to protect from radiation-induced myelosuppression, however little is known about the influence on intestinal injury. We evaluated G-CSF for its capacity to decrease the severity of radiation induced mucositis in vitro and in vivo . For in vitro test, G-CSF was administered to IEC-6 intestinal epithelial cells prior to damage induced by radiation. G-CSF prevented the decrease in IEC-6 cell viability and cytotoxicity induced by radiation. Treatment with G-CSF after irradiation also decreased the increase of the cleaved caspase-3, p53 and p21 by irradiation. For in vivo test, this study examined the radioprotective effects of G-CSF in intestinal damage, and survival in subtotal gamma- irradiated BALB/c mice. G-CSF (100 μg/kg per body weight) was subcutaneously injected once daily for three days before radiation. Examination 12 h after radiation (5 Gy) revealed that the G-CSF treated mice were significantly protected from apoptosis of jejunal crypt, compared with radiation controls. Compared with radiation controls 3.5 days after radiation (10 Gy), G-CSF treatment attenuated intestinal morphological changes. Further, G-CSF markedly improved attenuation of mortality in lethally-irradiated (10 Gy) mice. The present study suggests that G-CSF as a potential drug for protection from radiation-induced intestinal damage.