Impaired Adult Hippocampal Neurogenesis In Alzheimer?s Disease | 12533
Journal of Alzheimers Disease & Parkinsonism
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Alzheimer disease is accompanied by memory deficits. These deficits could be the consequence of changes in adult dentate
gyrus neurogenesis. As a first step to analyze those changes we have used a transgenic mouse model that shows an impaired
neurogenesis upon over expression of GSK3, a protein kinase that could be activated in Alzheimer disease (AD). Our results have
indicated a deficient morphology in adult newborn neurons that are unable to connect properly with the preexisting neurons.
These observations found in the mouse model were compared to the features found in the brain of Alzheimer disease patients
and some similarities were found. Our results suggest that an impaired neurogenesis may be responsible of the memory deficits
found in AD patients.
Jesus Avila is Professor and former Director of the Center of Molecular Biology Madrid, Spain. During the last thirty years he had been working in
neuron cytoskeleton. Now he studies the role of tau protein in neurodegenerative disorders tauopathies like Alzheimer's disease. He is member of
different Organizations like EMBO European Academy and the Spanish Royal Academy of Sciences; he is member of different Editorial Boards and
has more than 300 publications most of them related with Alzheimer's disease.
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