alexa
Reach Us +44-176-4910199
In The Fight Against Obesity: Two Peptides, One Route | 3394
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

In the fight against obesity: Two peptides, One route

2nd International Conference on Gastroenterology & Urology

Ayman I. Sayegh

ScientificTracks Abstracts: J Gastrointest Dig Syst

DOI: 10.4172/2161-069X.S1.012

Abstract
Obesity is a major epidemic which results from excessive energy intake and moderate energy expenditure. Because food is the main source of energy, understanding the mechanisms which control food intake forms the frontline in the fight against obesity. There are two general mechanisms which regulate food intake, short-term and long-term. The short-term mechanism, the focus of our laboratory, comprised of two components, meal size (MS) and intermeal meal interval (IMI) length, and it is regulated by peptides secreted from the gastrointestinal (GI) tract e.g. cholecystokinin (CCK) and gastrin releasing peptide (GRP) and stimulate central satiety areas to reduce MS and prolong the IMI. By utilizing a local, site-specific, microvascular catheterization technique we have shown that infusion of various forms of CCK and GRP into the celiac artery (supplies stomach and upper duodenum) and cranial mesenteric artery (supplies small and large intestine) in 1/10 of the doses given by other routes e.g. intraperitoneal injection reduce MS and prolong IMI length ten times more than those routes. Therefore, the gastrointestinal tract contains site(s) which regulates MS and IMI length, and the site-specific technique utilized in our work can be used as an anti-obesity drug delivery system for local targets in the gut.
Biography
Top