Journal of Gastrointestinal & Digestive System
Open Access

Abstract

This is a case of young male patient presented by chronic diarrhea which was attributed at first to intestinal lymphoma, but persistence of the symptoms pushed us for further evaluation to diagnose a rare hidden disease (DNLH) with selective IgA deficiency diffuse nodular lymphoid hyperplasia (DNLH) is a benign rare condition of unknown etiology characterized microscopically by diffuse hyperplasia of the lymphoid follicles (<0.5 cm in diameter) of the gastrointestinal tract mucosa. It can involve any part of the GIT, mainly the small intestine, but it may also involve the colon and rarely the stomach. The disease is usually associated with immunodeficiency syndromes such as common variable immunodeficiency or selective IgA deficiency syndrome. Its prognosis is usually benign but it carries the risk of malignant transformation characteristically to lymphoma.

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