Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 1636
Journal of Gastrointestinal & Digestive System received 1636 citations as per Google Scholar report
Journal of Gastrointestinal & Digestive System peer review process verified at publons
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- China National Knowledge Infrastructure (CNKI)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Management of chronic hepatitis C: A single center experience
International Conference on Digestive Diseases
Monir Hussein Bahgat, Shahira Aly El-Etreby and Salah El Gamal
Mansoura University, Egypt
ScientificTracks Abstracts: J Gastrointest Dig Syst
Abstract
Background & Aim: Treatment for HCV infection is undergoing a rapid evolution, offering new hope to both naïve and treatmentexperienced patients. Numerous highly effective, but expensive, direct acting antiviral (DAA) drugs active against different targets are now available. The aim of this study is to investigate the efficacy and safety of DAAs with and without PEG-IFN-α 2a, and/or ribavirin in treating chronic hepatitis C patients in Mansoura Specialized Medical Hospital. Material & Methods: This observational study involved 181 patients with chronic hepatitis C presented to our Viral Hepatitis Outpatient Clinic at Mansoura Specialized Medical Hospital for anti-viral therapy over an 18 months period from January 2015 to June 2016. A total of sex different regimens were used depending on the national and international changing guidelines. All patients were thoroughly assessed and followed up for SVR and side effects. Investigations involved Fibroscan & FIB-4 score for non-invasive assessment of liver fibrosis, and serial HCV RNA assay by PCR. Results: SVR12 for regimen 1 (PEG-IFN-α 2a + Sofosbuvir + Ribavirin) was 37/50 (74%), regimen 2 (Sofosbuvir + Ribavirin) was 40/56 (71%), regimen 3 (Sofosbuvir + Simeprevir) was 16/19 (78.9%), regimen 4 (Sofosbuvir + Daclatasvir ± Ribavirin) was 23/25 (92%), regimen 5 (Sofosbuvir + Ledipasvir) was 23/25 (92%), and regimen 6 (Paritprevir + Ombitasvir + Ritonavir) was 5/6 (83.3%). Commonly reported side effects (>10%) included fatigue (66%), flu like symptoms (48%), dyspnea (40%), psychiatric changes (30%), anemia (30%), cough (28%), nausea (24%), hypersensitivity (20%), rash (10%) for regimen 1. For regimen 2, fatigue (28.7%), cough (26.8%), and anemia (26.8%). For regimen 3, fatigue (26.3%), hypersensitivity (26.3%), and rash (15.8%). For the other 3 regimens fatigue was the only dominating side effect.Biography
Monir Hussein Bahgat has done his specialization in Internal Medicine in the year 1995. Currently, he is a Professor of Hepatology and Gastroenterology (Internal Medicine department), Manoura University Egypt. He is a member of EASL and IASL.
Email: monirbahgat@gmail.com
