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Modeling Stages Of Alzheimers Disease Induced By Different Doses Of Aluminum In Rats: Focus On Progression Of The Disease In Response To Time | 36503
ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
Open Access
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Background: AlzheimerâÂÂs disease (AD) is a neurodegenerative disorder characterized by progressive degeneration of the
hippocampal and cortical neurons that leads to impairment of memory and cognitive ability. It is the most common cause of
dementia and its incidence increases with age.
Objective: The study aimed to establish a model for different stages of AD in rats using different doses of ALCL3.6H2O.It also
aimed to determine the disease progression in the brain in response to time at all used dose levels of ALCL3.
Methods: For modeling stages of AD, different doses of ALCL3.6H2O (50, 70 and 100 mg/kg I.P for 6 weeks) were used.
Histopathological examinations were achieved in different brain regions; moreover biochemical measurements as B- amyloid,
ACHE and antioxidant parameters (SOD, TAC, and MDA) had been also estimated. In addition, the performance of rats was
examined in the Morris water maze test and Conditioned avoidance test. The progression of AD was also determined for all
used dose levels of ALCL3 after different periods (4, 5 and 6 weeks), as well as after one week of stopping injection and detected
by histopathological changes and degenerations in different brain regions.
Results: The present results showed that rats injected with ALCL3.6H2O at dose 70 mg/kg I.P for 6 weeks represent the most
exact model of AD where the hippocampus neuronal degeneration and pyknosis were more pronounced. This model was
sharply confirmed by biochemical and behavioral examinations. Mortality rates were taken in consideration. The progression
of the disease at all dose levels was time dependent, however the mortality rate was sever at dose 100 mg/kg at all times while
slowly degeneration was achieved at dose 50 mg/kg. In addition AD spread spontaneously even after one week stopping ALCL3
injection.
Conclusion: In the present study 70 mg/kg of Aluminum for 6 weeks represents the ideal model for AD. The progression of the
disease is time dependent and just starts spread spontaneously without more Aluminum exposure.
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