alexa
Reach Us +1-218-451-2974

GET THE APP

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Modifiers Of Amyloid Beta Toxicity In Alzheimer?s Disease | 21960
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 2590

Journal of Alzheimers Disease & Parkinsonism received 2590 citations as per Google Scholar report

Journal of Alzheimers Disease & Parkinsonism peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Modifiers of amyloid beta toxicity in Alzheimer?s disease

2nd International Conference on Alzheimers Disease and Dementia

Mayida Azhar

YRF: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460.S1.008

Abstract
One of the hallmarks of Alzheimer?s disease is the formation of extracellular senile plaques, preferentially composed of Amyloid beta protein. Processing of Amyloid precursor protein leads to the production of two reservoirs of A?: a secreted pool and a non-secreted cytoplasmic pool. Secreted A? contributes to extracellular plaques but despite various studies, the role of cytoplasmic A? in AD pathogenesis remains unclear. Indeed, the degree to which A? penetrates from vesicles through to the cytoplasm is not clear, however, it is likely that there is a dynamic equilibrium between all these pools. In this study, we hypothesise that cytoplasmic A? contributes to the toxicity of secreted A? through specific transmembrane interactions in our fly model of AD. Our preliminary experiments show that expression of aggregation prone form of extracellular A? leads to a reduction in longevity, locomotor deficits and the deposition of plaques while that of cytoplasmic A?, on the other hand, is non-toxic. Interestingly, the co-expression of cytoplasmic A? enhances the plaque deposition and toxicity of extracellular A?. To investigate how extracellular and cytoplasmic A? may interact we undertook an RNAi modifier screen of 115 candidate genes in Drosophila. We measured the increase in longevity caused by RNAi in flies expressing extracellular and cytoplasmic A?. Only those RNAi constructs that did not also cause increased longevity in control flies (those expressing only extracellular A? and those not expressing A?) were retained. By doing so, thirteen genes are found to specifically rescue the combined toxicity of cytoplasmic with extracellular A?. Flottilin-1 and ABCB8 (CG1356) are the best validated modifiers that we have detected. The longevity data is also supported by brain histology, gene and protein expression measurements. Obtained results suggest a synergistic interaction between two pools of A? and highlight the importance of transmembrane A? interactions in AD pathology.
Biography
Mayida Azhar is a 3rd year PhD student in department of Genetics, University of Cambridge.
https://bahigox.fun/ https://bahisjet.fun/ https://bahsegel.fun/ https://betboo.fun/ https://betdoksan.xyz/ https://betebetgiris.xyz/ https://betexper.fun/ https://betgram.fun/ https://betkanyon.fun/ https://betkolik.fun/
Top