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Modifiers Of Amyloid Beta Toxicity In Alzheimer?s Disease | 21960
Journal of Alzheimers Disease & Parkinsonism
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One of the hallmarks of Alzheimer?s disease is the formation of extracellular senile plaques, preferentially composed of
Amyloid beta protein. Processing of Amyloid precursor protein leads to the production of two reservoirs of A?: a secreted
pool and a non-secreted cytoplasmic pool. Secreted A? contributes to extracellular plaques but despite various studies, the
role of cytoplasmic A? in AD pathogenesis remains unclear. Indeed, the degree to which A? penetrates from vesicles through
to the cytoplasm is not clear, however, it is likely that there is a dynamic equilibrium between all these pools. In this study, we
hypothesise that cytoplasmic A? contributes to the toxicity of secreted A? through specific transmembrane interactions in our
fly model of AD. Our preliminary experiments show that expression of aggregation prone form of extracellular A? leads to a
reduction in longevity, locomotor deficits and the deposition of plaques while that of cytoplasmic A?, on the other hand, is
non-toxic. Interestingly, the co-expression of cytoplasmic A? enhances the plaque deposition and toxicity of extracellular A?.
To investigate how extracellular and cytoplasmic A? may interact we undertook an RNAi modifier screen of 115 candidate
genes in Drosophila. We measured the increase in longevity caused by RNAi in flies expressing extracellular and cytoplasmic
A?. Only those RNAi constructs that did not also cause increased longevity in control flies (those expressing only extracellular
A? and those not expressing A?) were retained. By doing so, thirteen genes are found to specifically rescue the combined
toxicity of cytoplasmic with extracellular A?. Flottilin-1 and ABCB8 (CG1356) are the best validated modifiers that we have
detected. The longevity data is also supported by brain histology, gene and protein expression measurements. Obtained results
suggest a synergistic interaction between two pools of A? and highlight the importance of transmembrane A? interactions in
Mayida Azhar is a 3rd year PhD student in department of Genetics, University of Cambridge.
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