Reach Us +1-218-451-2974


Neuro-degeneration: Inhibition Of Protein Biosynthesis, Food And Infections | 12521
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences
Google scholar citation report
Citations : 2275

Journal of Alzheimers Disease & Parkinsonism received 2275 citations as per google scholar report

Journal of Alzheimers Disease & Parkinsonism peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Neuro-degeneration: Inhibition of protein biosynthesis, food and infections

International Conference on Psychology, Autism and Alzheimers Disease

Elena Paley

Accepted Abstracts: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460.S1.004

Biogenic amines, decarboxylated analogs of amino acids act as competitive inhibitors of aminoacyl-tRNA synthetases, enzymes of protein biosynthesis. At high concentration, biogenic amines can induce cell death via arrest of protein biosynthesis. Human cells and also microorganisms associated with food products and environment produce biogenic amines. The content of biogenic amines such as tyramine, histamine and tryptamine is high in common food products. Tryptamine appears as a suitable etiological factor killing neurons in human brain because in contrast to tyramine and histamine, tryptamine easily crosses blood-brain barrier (i) and tryptophan is not synthesized in human body and is a least available amino acid in food (ii). Thus the tryptamine inhibitory effect cannot be easily compensated by tryptophan. By other words, increased tryptamine prevents incorporation of tryptophan in proteins. The blockage of protein biosynthesis leads in cell death. The neuronal death is a major feature of all neurodegenerative diseases. Our experiments on human neuronal cells and mice demonstrate a massive neuronal loss induced by tryptamine at the concentrations inhibiting tryptophanyl-tRNA synthetase. Moreover amyloidosis and formation of neurofibrillary tangles, the manifestations of neurodegeneration were also induced by tryptamine in human neuronal cultured cells and mouse brain. Histologically manifestations induced by tryptamine are similar to those we found in autopsy brain of patients with Alzheimer?s disease. For further analysis of samples of Alzheimer?s disease patients and healthy controls we developed specific test, which reveals a link between microorganisms and disease.
Elena Paley has completed her Ph.D. studies at the Engelhardt Institute of Molecular Biology, Moscow, Russia (1987) and postdoctoral studies at the Tel Aviv University School of Life Sciences, Israel. She is the adjunct faculty of Nova Southeastern University, FL, USA and founder and principal scientist of Expert Biomed, Inc., FL, USA. She has published papers in the field of protein biosynthesis, cell research, neurodegeneration and cancer in reputed journals and she is the inventor of USA issued and pending patents related to tryptamine-induced model of neurodegeneration.