Neurodegenerative Cascades In Alzheimer?s Disease | 12548
Journal of Alzheimers Disease & Parkinsonism
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The aspartyl protease ?-site A?PP-cleaving enzyme 1 (BACE1) catalyzes the rate-limiting step in A? production, a peptide at
the nexus of neurodegenerative cascades in Alzheimer Disease dementia. Leptin may offer protection against Alzheimer?s
dementia as this adipocytokine can reduce A? production and decrease BACE1 activity and expression levels. However, the
signaling cascades involved in the leptin-induced mitigation in A? levels and BACE1 expression levels have not been elucidated.
We have demonstrated that NF-?B positively regulates BACE1 transcription. NF-?B activity is tightly regulated by the mammalian
sirtuin SIRT1. Multiple studies have cogently evinced that leptin activates the metabolic master regulator SIRT1. In this study, we
determined the extent to which SIRT1 expression and activity regulate the leptin-induced attenuation in BACE1 expression and
A? levels. This study also elucidated and delineated the signal transduction pathways involved in the leptin induced mitigation
in BACE1 expression.
Othman Ghribi has completed his Ph.D. in 1994 at the University Ren? Descartes, Partis France, and postdoctoral studies from the University of
Quebec and the University of Virginia. He has published more than 60 papers in reputed journals and serving as a Senior Editor of The Journal
of Alzheimer?s Disease and is a member on the editorial board of the Journal of Alzheimer?s Disease and Parkinsonism, American Journal of
Neurodegenerative Diseases, and Current Alzheimer Research.
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