Primary Gastric Yolk Sac Tumor With Liver Metastases In A 66-year-old Patient: A Case Report | 59518
Journal of Gastrointestinal & Digestive System
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Yolk sac tumor (YST) of the stomach is extremely rare, with only several cases reported in the English literature. We present a case
of primary gastric yolk sac tumor with liver metastases in a 66-year-old male. Preoperative diagnosis was poorly differentiated
as adenocarcinoma of stomach. A total gastrectomy was performed. The tumor, with a maximum size of 6.0 cm, was composed
microscopically of neoplastic cells with pale eosinophilic cytoplasm. Tumor cells were arranged into solid and papillary structures
with several Schiller-Duval bodies. Other components of germ cell tumors, such as embryonal carcinomas and choriocarcinoma,
were not identified. The tumor cells were positive for AFP, СК 18, СК 20, SALL4, glypican3, but were negative for PLAP, OCT ¾, СК
7 by immunohisochemistry. The surgical margins were histologically negative, 12 of 22 resected lymph nodes had metastases. The
laboratory findings showed high serum levels of AFP (2502ng/mL); testicles were symmetric with normal size. Primary pure gastric
yolk sac tumor is a very rare entity. The rarity of gastric YST makes this diagnosis complicated. However, awareness of this unusual
entity and its distinctive immunohistochemical profile invariably leads to a correct diagnosis.