alexa Progranulin Deficiency Increases Vulnerability Of Human Neuroblastoma SH-SY5Y Cells To Serum Withdrawal-induced Apoptosis
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Alzheimers Disease and Dementia
September 23-25, 2014 Valencia Convention Centre, Spain

Angeles Martin Requero, Carolina Alquezar and Ana de la Encarnacion
Posters: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.009
Abstract
Null mutations in GRN are associated with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). However the influence of progranulin (PGRN) deficiency on neurodegenation is largely unknown. In neuroblastoma cells, silencing of GRN gene causes significantly reduced cell survival after serum withdrawal. It was observed that PGRN deficient cells (KD GRN) are more vulnerable to serum deprivation than control cells. The supplementation of recombinant human PGRN restored the survival of KD cells. The following observations suggest that modulation of the CDK6/pRb pathway secondary to changes in the activity of the PI3K/Akt and ERK1/2 signaling pathways, induced by PGRN levels is involved in the altered regulation of serum deprivation-induced apoptosis. (i) The specific CDK6 inhibitors, sodium butyrate or PD332991 sensitized control SH-S5Y5 cells to serum deprivation-induced apoptosis without affecting survival of PGRN deficient cells. (ii) CDK6/pRb seems to be downstream of the PI3K/Aktand ERK1/2pathways since their specific inhibitor, Ly294002 and PD98059 were able to decrease CDK6 activity and induced death of control SH-SY5Y cells. (iii) PGRN deficient cells show reduced stimulation of Akt, ERK1/2, and CDK6-associated kinase activities than in control cells in the absence of serum. These observations highlight the important role of PGRN-mediated stimulation of the PI3K/Akt/ERK1/2 and CDK6/pRb pathways in determining the cell fate survival/death under serum deprivation.
Biography
Angeles Martin Requero is Doctor of Biological Sciences, Complutense University of Madrid in 1978. she completed Postdoctoral Fellow in University of Pennsylvania, Philadelphia, USA in 1979-1982. She worked as as a Professor in University of Extremadura (1982-1983). Scientific Holder in 1985. In 1996-1997 she worked as a Visiting Scientist in Medical Scholl, University of California (UCLA), Los Angeles, USA. In 2008 she is a Research Scientist.she currently heads the laboratory devoted to ?study the cellular and molecular basis of Alzheimer?s disease and other dementias, ? in the Department of Cellular and Molecular Medicine, Center for Biological Research (CSIC). She has authored more than 50 publications in international journals and a hundred communications in national and international conferences.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords