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Rate Of Helicobacter Pylori Eradication By Levofloxacin Based And Clarithromycin Based Sequential Therapy Regimens At Tertiary Care Hospital | 102311
ISSN: 2161-069X
Journal of Gastrointestinal & Digestive System
Open Access
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Introduction: Helicobacter pylori infection has been recognized as one of the most common chronic bacterial infections in
humans. Many H. pylori eradication regimens have been described. There are little data reporting their efficacy or integration in
routine clinical practice.
Objective: The aim of the current study is to find the rate of H. pylori eradication by levofloxacin based and clarithromycin based
sequential therapy regimens at tertiary care hospital.
Study design: Study was conducted on out patients at Department of Gastroenterology, Liaquat National Hospital, Karachi.
Duration of study: Six months from 23th Oct 2016 to 23th Apr 2017.
Subject & Methods: All in patients who fulfilled the inclusion criteria in the Department of Gastroenterology, Liaquat National
Hospital, Karachi were included in the study. After taking informed written consent history, clinical examination, upper GI
endoscopy was performed levofolxacin and clarithromycin based sequential H. pylori eradication was given. Eradication was
checked by performing stool for H. pylori eradication. All the collected information was entered in the prescribed Performa.
Results: A total 254 patients were included in our study. 106 (41.7%) were female and 148 (58.2%) were male. Mean duration of
dyspepsia was 5.03�1.24 months. Eradication rate was 95% with levofloxacin based sequential therapy and 85% with clarithromycin
based regime.
Conclusion: The eradication rate with levofloxacin sequential therapy was better than clarithromycin based regime, could be due
to high resistance in our population so it is suggested to prefer levofloxacin based regime in our day to day practice.