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Role Of Tight Junction In Urinary Ca++ Homeostasis | 3540
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Role of tight junction in urinary Ca++ homeostasis

2nd International Conference on Gastroenterology & Urology

Jianghui Hou

AcceptedAbstracts: J Gastrointest Dig Syst

DOI: 10.4172/2161-069X.S1.019

Abstract
Calcium nephrolithiasis is a common condition. Family-based genetic linkage studies and genome-wide association studies (GWASs) have uncovered a run of important candidate genes involved in renal Ca++ disorders and kidney stone diseases. The susceptible genes include membrane proteins such as NKCC2, ROMK and ClCkb/Barttin that underlie renal salt excretion; tight junction proteins such as claudin-14, -16 and -19 that underlie renal Ca++ excretion; and the Ca++ sensing receptor (CaSR) that provides a sensing mechanism for the kidney to regulate salt, water and Ca++ homeostasis. Biological and physiological analyses have revealed the cellular mechanism for transepithelial Ca++ transport in the kidney that depends on the tight junction to reabsorb Ca++ through a driving force generated by transepithelial salt gradient via the concerted action of these gene products. Although the individual pathogenic weight of the susceptible genes in nephrolithiasis remains unclear, perturbation of their expression or function compromises the different steps within the integrated pathway for Ca++ reabsorption, providing a physiological basis for diagnosing and managing kidney stone diseases.
Biography
Jianghui Hou has completed his Ph.D. at the age of 26 years from the University of Edinburgh School of Medicine (UK) and postdoctoral studies from Harvard University School of Medicine (US). He was appointed Assistant Professor (tenure track) of Medicine by Washington University St. Louis School of Medicine (US) since 2009. He has published more than 20 papers in reputed journals and received the Young Investigator Prize of Chinese Society of Nephrology.
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