Synergistic Effects Of Cyclooxygenase-2 Genotypes And Smoking Habit On Gastric Cancer In Taiwan | 3500
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Synergistic effects of cyclooxygenase-2 genotypes and smoking habit on gastric cancer in Taiwan

2nd International Conference on Gastroenterology & Urology

Meng Hsuan Lee

Posters: J Gastrointest Dig Syst

DOI: 10.4172/2161-069X.S1.018

Aim: The relationship between COX-2 gene and gastric cancer risk is still ambiguous. In this study, the association and interaction of genotypic polymorphisms in cyclooxygenase 2 (Cox-2) gene and smoking habits with gastric cancer susceptibility are investigated. Materials & Methods: Up to 136 patients with gastric cancer and 560 healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped by PCR-RFLP method. We investigated six polymorphic variants of Cox-2, including G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, and analyzed the association of specific genotype with susceptibility to gastric cancer. Results: The data showed that although for each genotype of Cox-2 G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, there is no difference in the distribution between the gastric cancer and control groups (P>0.05), the analysis of joint effect for Cox-2 G-765C and intron 6 showed that individuals with GC at G-765C and GG or AG+AA at intron 6 present a slightly higher potential for developing gastric cancer than other groups. Also, the GC genotype at G-765C plus smoking habit performed synergistic effects on gastric cancer susceptibility. Conclusion: Our findings suggest that the C allele of Cox-2 G-765C may be responsible for gastric cancer etiology and may be useful in early detection and prediction of gastric cancer.