alexa Tau PET Imaging: New Insight Into Early Diagnosis Of Tauopathy
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Alzheimers Disease and Dementia
September 23-25, 2014 Valencia Convention Centre, Spain

Naruhiko Sahara
ScientificTracks Abstracts: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.006
Abstract
Accumulation of intracellular neurofibrillary tangles (NFTs) consisting of microtubule-associated protein tau is a major hallmark of Alzheimer?s disease (AD) and related neurodegenerative diseases regarded as ?tauopathies?. Findings of tau gene mutations in FTDP-17-tau families have provided direct evidence that tau abnormalities alone can induce neurodegenerative disorders. Therefore, visualization of tau accumulation would offer a reliable, objective indicator to diagnose of tauopathy and to assess the disease progression. Positron emission tomography (PET) imaging of tau lesions is currently available using several tau PET ligands including [11C]PBB3. However, more compelling in vivo and neuropathological evidence supporting binding of PBB3 to tau lesions in diverse tauopathies (e.g., AD, Progressive supranuclear palsy, Corticobasal degeneration, Argyrophilic grain disease, Pick?s disease) is still required since the presence of tau pathologies in scanned subjects has not been confirmed in the aforementioned clinical PET assay. PBB3 is a fluorescent compound, and is accordingly supposed to be useful for multimodal imaging studies, potentially allowing us to validate its binding to diverse tau inclusions (e.g., NFTs, globus NFTs, astrocytic plaques, tufted astrocytes, coiled bodies, Pick bodies, and ballooned neurons) by histological methods. The author will present progress of pathological characteristics of PBB3 binding on tau lesions in brains of human subjects with various tauopathies and tau transgenic mice. Moreover, ongoing studies will be introduced for the usefulness of tau PET ligands in the early detection of tauopathies.
Biography
Naruhiko Sahara received his BS from the Tokyo University of Science, Canada in 1988. MS from Tokyo University of Science in 1990 in the Department of Biochemistry and PhD from Tokyo University of Science in the Department of Biochemistry in 1998. From 1992-1998, he worked as a Research Technologist in the Department of Molecular Biology in Tokyo Institute of Psychiatry, Tokyo, Japan. 1998-2000 as a Research associate in Department of Neuroscience, Osaka City University, Japan. 2000-2003 Research fellow in Laboratory of Neurochemistry, Mayo Clinic, Jacksonville. From 2003-2006, he worked as a Staff Scientist in Laboratory for Alzheimer?s Disease, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN) in Japan. 2006-2008 he was Deputy Laboratory Head in Laboratory for Alzheimer?s Disease, Brain Scinence Institute, RIKEN in Japan. From 2008-2009, Senior Research Associate, Laboratory of Neurodegenerative Disease Modeling, Mayo Clinic. 2009-2010, he worked as an Associate Consultant in Laboratory of Neurodegenerative Disease Modeling in Mayo Clinic, Jacksonville. 2010-2013 as Assistant Professor in Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville. 2013-present he is working as a Senior Researcher and Assistant Director, Neuromolecular Dynamics Team in Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords