alexa The A? Oligomer Count In CSF Is A Useful Biomarker For Alzheimer?s Disease | 21908
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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2nd International Conference on Alzheimers Disease and Dementia

Dieter Willbold
ScientificTracks Abstracts: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.006
Abstract
Alzheimer?s disease (AD) is a fatal neurodegenerative and progressive disorder. Currently, no reliable biomarkers for presymptomatic diagnosis or therapy monitoring are available. Recent studies indicate that especially soluble amyloid beta peptide (A?) oligomers are the major toxic species during development and progression of AD. Therefore, we suggest that the number of A? oligomers in body fluids can be used as the most relevant and direct biomarker for AD. We developed a surfacebased fluorescence intensity distribution analysis (sFIDA) assay for specific quantification of A? oligomers with single particle sensitivity. We challenged the assay with cerebrospinal fluid (CSF) samples from 14 AD patients and 12 age-matched control subjects. The A? oligomer count revealed a surprisingly clear distinction between both groups. All samples of the control group showed homogenously low numbers of A? oligomers, while the samples of the AD group exhibited significantly higher levels of A? oligomers. The A? oligomer levels clearly correlated with the patients? mini-mental state examination (MMSE) scores. Our results support the idea that A? oligomers play a crucial role in AD pathology and in turn can be used as a diagnostic biomarker. The sFIDA assay is able to reliably and specifically quantify A? oligomers in human CSF. In addition, the correlation between MMSE scores and A? oligomer concentrations in CSF suggests that the quantity of A? oligomers in CSF correlates with the severity of the disease. This will allow to evaluate and to monitor anti-A?-targeted therapies based on the A? oligomer counts in treated individuals.
Biography
Dieter Willbold studied biochemistry in Tubingen (Germany), Bayreuth (Germany) and Boulder (Colorado, USA). He completed his PhD in 1994 at the University of Bayreuth. After some more years in Bayreuth and a couple of research visits, e.g. at the Sackler School of Medicine of the Tel-Aviv University, he headed a junior research group at the Institute for Molecular Biotechnology in Jena. In 2001 he became an Associate Professor at the Heinrich-Heine-University of D?sseldorf. Since 2004, he is Full Professor at the Institute of Physical Biology in Dusseldorf and director of the Institute of Complex Systems in the Research Centre J?lich.
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