The Aid Of Ephedrine HCL, Curcumin And Turmerone In Neurogenesis And Inhibition Of Beta-amyloid Plaques In Transgenic Mice Models | 46229
Journal of Alzheimers Disease & Parkinsonism
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
This study was done to demonstrate the effects of Ephedrine HCL, Turmerone & Curcumin in Neurogenesis and
Inhibition of Beta Amyloids in Transgenic Mice. The transgenic mice models used contain mutations associated with
familial Alzheimer's disease (APP Swedish, MAPT P301L and PSEN1 M146V). These mice develop age-related, progressive
neuropathology including plaques and tangles. Ten-month-old male and female APPSw Tg+ and Tg− mice from 12 litters were
randomly split between treatment groups. Tg+ mice were fed either chow containing a low dose of curcumin (160 ppm; n=9; a
high dose of curcumin (5000 ppm; n=6), or no drug (n=8) for 6 months. Mice with low and high dose of curcumin were given
specific doses of 0.02% Ephedrine HCL injection every 72 hours and underwent a single intracerebroventricular injection of 3
mg ar-turmerone. To evaluate whether curcumin treatment affected plaque pathology, cryostat hemibrain sections from Tg+
control and Tg+ low-dose curcumin-treated mice were immunostained with an antibody against Aβ1–13(DAE). Two-factor
ANOVA revealed a significant reduction in plaque burden in curcumin, Ephedrine HCL and turmerone treated animals (F
(1.60)=4.74; p=0.03), in which amyloid burden was decreased by 43.6% in treated animals compared with untreated animals.
Soluble Aβ in Tg+ untreated and Tg+ low-dose curcumin mice were measured by sandwich ELISA. Two-way ANOVA showed
significant treatment effects in decreasing the levels of soluble Aβ (*p<0.05). Underlying mechanistic pathways that might
link curcumin treatment to increased cognition and neurogenesis via exon array analysis of cortical and hippocampal mRNA
transcription showed a positive result.