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The In Vivo Triad Behind The Neuromodulatory Effect Of Bauhinia Variegata L | 57449
ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
Open Access
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
LPS is a well established model for induction of neuroinflammation and amyloidogenesis widely used to study the pathway
of many neurodegenerative diseases like Alzheimer’s disease. Phenolics are widely known for their different beneficial
characteristics, they could be considered as promising therapeutic agents against neurodegenerative diseases.
In this study, hydroalcohol extract of leaves and stalks of Bauhinia variegata has been shown to ameliorate neurodegenerative
diseases owing to the high phenolic content including flavonoids.
The effect of the plant was studied in a dose dependent manner in comparision to herbal (green tea) and non-herbal
reference (donepezil HCl) standards and the in vivo study was designed in what is promised to be the in vivo triad. The peak of
the triad was represented by improvement of cognitive performance in in vivo behavioural tests (Y maze and water maze). The
first side of the triad base was represented by biochemical analysis done on brain homogenates by ELISA where a recognizable
decrease in amyloid beta 42 was observed by 39.89%, 59.8%, 71.3% and 78.49% after administration of doses 50, 100, 200 and
400 mg/kg of the studied extract respectively in addition to an increase in SOD levels by 80%, 2.4 folds, 4.5 folds and 5.6 folds
after treatment with the same doses respectively.
The second side of the triad base was represented by histopathological investigation which confirmed the previous findings.
According, Bauhinia variegata could be considered as a phenolic capsule that can bombard and delay progression of
neurodegenerative diseases.