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The Relationship Between A Depressive Endophenotype Of Cognitive Impairment And Suicidal Ideation | 12501
Journal of Alzheimers Disease & Parkinsonism
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Older adults have higher rates of suicide than any other age group. While depression is a strong predictor of suicide in the
elderly, more research is needed investigating this risk in elders with cognitive dysfunction. Our research has demonstrated
that an explicit cluster of depression symptoms (called the DepE) rather than total depression scores are related to cognitive
impairment, and can be used to identify a subgroup of individuals at greater risk for developing mild cognitive impairment and
Alzheimer?s disease. The goal of this study was to examine the relationship between DepE and suicidal ideation. Data on 582
rural dwelling participants from Project FRONTIER were analyzed for this study. Suicidal ideation was measured via the suicidal
ideation subscale of the GDS 30 (GDS-SI). Age, education and gender were covariates.
Results of the linear regression indicated that DepE significantly increased scores on the GDS-SI (B=.47, p<.001), independent
of age, education, or gender. Next, we split the sample by high and low suicidal ideation using the GDS-SI cut score of 3. A logistic
regression was performed with the covariates and DepE entered in to the model. The results indicated that DepE was the only
significant predictor of suicidal ideation (odds ratio [OR]=3.08, 95% CI= 2.5-3.9). For every one point increase on the DepE scale,
suicidal ideation went up by a factor of three. These results suggest that the DepE is strongly related to an increase in suicidal
ideation in the elderly. Identifying sub groups of elders at greater risk of suicidal ideation may help practitioners identify novel
treatment and preventative opportunities.
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