Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us +44 1223 790975


Unravelling The Spontaneous Self-assembly Of α-helical Aβ-peptides In Lipid Membranes By Analytical And Multiscale Approach | 12475
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Unravelling the spontaneous self-assembly of α-helical Aβ-peptides in lipid membranes by analytical and multiscale approach

International Conference on Psychology, Autism and Alzheimers Disease

Martina Pannuzzo

ScientificTracks Abstracts: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460.S1.002

The mechanisms underlying the neurotoxicity in Alzheimer�s disease are still under intense debate. As experimentally shown, Aβ peptide, primary component of amyloid plaques, self assembles to aggregate that permeabilize membranes. By a combination of multi scale simulations and analytical theory, we unveiled the early steps of the spontaneous self-assembly of membrane-embedded α-helical Aβ (1-40) peptides. The presence of distorted structures called ��frustrated helices�� was predicted and confirmed by large scale Coarse Grained simulations while the stability of these helical structures has been validated by fully atomistic simulations. In addition, CG simulations clearly evidenced mechanical stress on the membrane structure induced by the presence of the growing assemblies. We believe that these findings will provide an alternative view to the traditional models that consider a conformational transition towards b-sheet rich structures as a prerequisite for triggering membrane damage, suggesting new potential targets for the drug treatment.
Martina Pannuzzo has completed her Ph.D. in Chemical Science in 2012 from University of Catania (Italy), and she has been awarded for the best Italian Ph.D. thesis in Theoretical Biophysics, 2010-2012. She got several fellowships to visit important research groups in the field of Computational Biophysics in the Netherlands and Canada. She is currently postdoctoral researcher in Computational Biology at the University of Erlangen- Nuremberg, working in the field of membrane biophysics. She is the author of 9 papers published in well reputed chemical-physics journals.