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Research Article Open Access
The Operculina turpethum (Fam. Convolvulaceae) is a traditional medicinal plant for the treatment of anthelmintic, expectorant, antipyretic, anti-inflammatory and purgative. The work reached the acute toxicity of Operculina turpethum and its action on the ethanolic extract of the central nervous system (CNS) because on data in the literature have been found of pharmacological activity of this plant in the CNS. The Operculina turpethum was extracted with ethanol and investigated for its CNS activity of experimental model in mice. The extract produce a dose dependent reduction of the onset and duration of pentobarbitone induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole cross at the dose level of 250 mg/kg and 500 mg/kg body weight. At the same dose labels, the extract dose dependently inhibited acetic acid induced writhing in mice. This study suggested that the extract possess CNS depressant activity.
Operculina turpethum, Central nervous system, Analgesic activity, Operculina turpethum, Central nervous system, Analgesic activity