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Research Article Open Access
We proposed and demonstrated an effective and non-destructive centrifugal microfluidic sensor (CMS) for analysis of organophosphorus pesticides (OPPs). The CMS was designed to have a sequential sample injection with two capillary valves. The actuation mechanism of CMS was controlled by centrifugal force, i.e. relative centrifugal force (×g). The OPPs analyte in CMS could be successfully derived into a mixer at 34 g and then spined into a detection reservoir at 537 g. The experiment results indicated that limit of detection for OPPs using CMS was 0.05 ppm, a linear relationship between OPPs logarithmic concentration (ppm) and inhibition rate (%) was 0.9215. Furthermore, series fresh vegetables were extracted and assayed for OPPs residue detection by using CMS. It was effective for OPPs detection. A non-destructive, rapid, reliable, and sensitive approach to OPPs analysis was demonstrated. This in turn opens up opportunities for healthcare applications, notably environmental monitoring, foods safety and other fields.
Centrifugal microfluidic chip, Organophosphorus pesticide detection,Capillary valve, Biomedical Sensor,Biosensors Application