alexa Abstract | Microsomal Prostaglandin E Synthase-1 in Respiratory Diseases
1165-158X

Cellular and Molecular Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Microsomal prostaglandin E synthase-1 [mPGES-1] is today a well recognized target for the development of nextgeneration anti-inflammatory drugs with improved selectivity and safety compared to nonsteroidal anti-inflammatory drugs [NSAIDs]. mPGES-1 is a terminal prostaglandin E2 [PGE2] synthase in the cyclooxygenase pathway. Among the three PGE synthases, namely cytosolic prostaglandin E synthase [cPGES], mPGES-1, and mPGES-2, mPGES-1 is the major isoform for producing PGE2 during inflammation. PGE2 is the major eicosanoid product of the respiratory system and is overproduced and secreted by the airway epithelium, smooth muscle, dendritic cells, macrophages, and fibroblasts in airway inflammatory diseases, including chronic obstructive pulmonary disease [COPD], acute lung inflammation, allergic asthma, and cancer. Recent studies using mPGES-1 knockout mice demonstrated that mPGES-1 contributes to the inflammatory PGE2 production involved in airway inflammation and respiratory regulation. In this review, we focus on mPGES-1 in respiratory diseases with the aim to cover the most recent advances in the understanding of mPGES-1 in airway inflammation, COPD, allergic airway diseases, respiratory response to hypoxia, and lung cancers.

To read the full article Peer-reviewed Article PDF image

Author(s): Dongmei Wu

Keywords

Microsomal prostaglandin E synthase-1, Chronic obstructive pulmonary disease [COPD], Acute lung inflammation, Allergic airway diseases, Apnea, Lung cancer

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords