Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 2154

Journal of Biotechnology & Biomaterials received 2154 citations as per Google Scholar report

Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Access to Global Online Research in Agriculture (AGORA)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • ICMJE
Recommended Journals
Share This Page

Ribokinase: A possible target for chemotherapy in protozoans

World Bio Summit & Expo

Patrick O Ogbunude

University of Nigeria, Nigeria

ScientificTracks Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.C1.046

Abstract
The development of anti-parasitic agent is quite challenging particularly when exploiting biochemical differences between the parasite and the host. However, with post-genome bioinformatics and experimental research, drug targets can be more easily identified. Ribose metabolism in protozoans is of interest because protozoa in general are auxotrophic for purines and acquire these nutrients from the hosts. Ribose is utilized in the production of ribose 5-phosphate required for the synthesis of 5-phosphoribosyl- 1-pyrophosphate that is used with purine bases for the synthesis of nucleic acids. The enzyme responsible for the conversion of ribose to ribose 5-phosphate is ribokinase. The gene for ribokinase of Leishmania was cloned and expressed in E. coli. It has 990 base pairs and encodes a 329 amino acid protein. Biochemical characteristic of the enzyme shows that ribokinase is highly specific for D-ribose although it insignificantly phosphorylates other five- and six-carbon sugars like D-arabinose, D-xylose, D-galactose and D-fructose. The catalytic efficiency for D-ribose catalysis ranges from 10.8 s-1 mM-1 to 40.6 s-1 mM-1. The enzyme has absolute requirement for inorganic phosphate.
Biography

Patrick O Ogbunude obtained a Master’s degree from University of Alberta, Canada and PhD from Ahmadu Bello University in Nigeria and thereafter did research in several laboratories in various places including defunct International Laboratory for Research in Animal Diseases, Nairobi Kenya, King Faisal Special Hospital and Research Centre, Riyadh Kingdom of Saudi Arabia and The University of Glasgow, Scotland, UK. He has made several seminal discoveries like the identification of purine nucleoside hydrolase activity in trypanosomes and channel like properties of nucleoside transporters in Leishmania. He has considerable experience in research with over fifty-six research papers in peer reviewed journals.

Email: ogbunudejim@yahoo.co.uk

Top