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In Association with
Thermoresponsive triblock copolymers as injectable gels
Annual Conference and Expo on Biomaterials
Theoni K Georgiou
Imperial College London, UK
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Thermoresponsive polymers i.e. temperature-responsive polymers can be used an injectable gels in tissue engineering because they have the ability to in situ encapsulate stem cells. Thus a scaffold can be created in the body without using invasive surgical techniques to implant it. The gelation point i.e. the temperature that the gel is been informed is critical and need to be controlled well in order for the polymers to be applicable for this application. In our group we have synthesized and characterized a variety of thermoresponsive multiblock copolymers where the structural parameters (molar mass, composition, architecture and chemistry) were systematically varied to mainly investigate how the gelation point is affected by these structure parameters. The optimum molar mass was found to be around 7000 g/mol and the optimum hydrophobic content around 35 wt%. Interestingly the position of the block within the polymer, thus the polymer architecture also influenced the thermoresponsive, sol-gel transition of the polymer. Specifically it was demonstrated that when the hydrophobic block is in the middle that results in a more clear and sharp sol-gel transition. In summary we were able to prove that the sol-gel transition and the gelation temperature can be tailored that is essential for the application by tailoring the structural properties of the polymer.Biography
Theoni K Georgiou has obtained her BSc in Chemistry from the University of Cyprus in 2001 followed by a PhD in 2006 in Polymer Chemistry. She has worked as a Postdoctoral Fellow with Professor Antonios G. Mikos at the Department of Bioengineering at Rice University in the USA. In October 2007, after being awarded with RCUK Academic Fellowship, she moved to UK to join the Department of Chemistry at the University of Hull. In January 2014 she has joined the Department of Materials at ICL. Her research interests involve synthesis and characterization of polymers and their evaluation in a variety of biological applications.
Email: t.georgiou@imperial.ac.uk
