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My research focuses primarily on developing nanotechnology-based formulations for targeting therapeutics to tumors. My research also focuses on the development and pharmacokinetic evaluation of formulations to overcome various physiological barriers (nasal, periodontal, skin, corneal etc.). In my lab, we are developing various nanotechnology-based delivery systems to target drugs/macromolecules to resistant-tumors, to overcome the blood-brain barrier in diseases like migraine and cerebral palsy, and to overcome gastrointestinal epithelial barrier. The other areas of my research interests include population pharmacokinetics and modeling of drugs used in special populations; formulation and evaluation of sterile and non-sterile extemporaneously compounded preparations; biopharmaceutic and pharmacokinetic evaluation of new chemical entities (NCE's); and development of technology-based visual aids for the teaching pharmaceutics and pharmacokinetics.
In vivo Efficacy of PAMAM-Dendrimer-Cisplatin Complexes in SKOV-3 Xenografted Balb/C Nude Mice
Venkata K Yellepeddi, Kiran Kumar Vangara and Srinath Palakurthi
Research Article: J Biotechnol Biomaterial 2013, S13:003
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