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Dr Kagawa obtained PhD with study of cytochrome P450s working with Dr Ryo Sato Osaka University who discovered P450 He moved to University of Texas Southwestern Medical Center at Dallas and studied the cAMPdependent gene regulation of steroidogenic P450s with Dr Michael R Waterman He moved to Vanderbilt University Nashville TN in 1992 At Vanderbilt University he purified a few 61549;g of transcription factors and succeeded to identify them Pbx1 and 3 that are involved in the cAMPdependent gene expression of steroidogenic P450s and also essential for adrenal formation during the gestation He was also interested in the heterologous expression of mammalian P450s in E coli and established methods for the efficient expression and purification of hydrophobic P450s including aromatase CYP19 Because large amounts of highly purified P450s became available he is interested in studying detailed reaction mechanisms of P450s based on the 3D structure
Physiological role of P450s, drug metabolism, biosynthesis of steroid hormones, environmental hormones, reaction mechanisms of P450s, structure-function relationship of P450, role and regulation of aromatase, heterologous expression of hydrophobic membrane proteins in E. coli.Network
Dimitrios Kalpaxis was born in Moulki of Corinth in 1951. He is married and has two children. He studied Biology (1970-1974) and Chemistry (1975-1979) in University of Patras. He was a post-graduate student in the School of Sciences of University of Patras and received his PhD in 1981. He worked as a Research Fellow (1980-1982), Lecturer (1982-1986), Assistant Professor (1986-1996), Associate Professor (1996-2003) and Professor (2003-today) at the School of Medicine of University of Patras. He has been a Visiting Scholar at the School of Medicine of Nurnberg University (1988, 1989) and Visiting Research Fellow at the Max-Plank Institute of Berlin (2000). He has given a series of lectures and seminars in Academic and Research Centers of Europe. His research interests are focused on the Biochemistry field, in particular on the structural analysis of cartilage components, the kinetic analysis of dehydrogenases, the structure and function of the protein-synthesizing machine and the mechanism of action of antibiotics. He has published extensively in international journals of high impact factor and books, and has presented his research in various international conferences and workshops. He is a member of the editorial board of the journal Open Enzyme Inhibition Journal and Community Medicine & Health Education, reviewer in 18 international journals, reviewer of research proposals submitted in national and international financial agencies, and member of 6 scientific societies. He has been director of the post-graduate Programme in Basic Medicinal Sciences of University of Patras (2006-2010), member of the Committee for Post-Graduate Studies (2006-2008), and member of the Research Committee ( 2007-2010) of University of Patras. In 2010, he was elected to be Vice Rector in University of Patras, for Strategic Research Planning and Development (2010-2014).
Dr. Depeng Jiang is an assistant professor in the department of Community Health Sciences of University of Manitoba and presently serving as a director of Biostatistical Consulting Unit. He is also adjunct professor with Dalla Lana School of Public Health of University of Toronto and with Department of Psychology of York University. Dr. Jiang had many years of experience in providing statistical consulting to a broad range of clients and training students and researchers on the conduct of statistical analyses. The thrust element of his research is being innovative and conducting research that has high broader impact in quantitative methods for medical science and public health.
Longitudinal data analysis and multilevel model
Person-centered statistical approaches in health science
Latent variable analysis and structural equation model
Clinical trial design and intervention evaluation
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