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ISSN:2167-7964
OMICS Journal of Radiology
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Are Variations of Paranasal Sinuses and Infundibular Trace Length Responsible for Development of Maxillary Sinusitis?

Paşaoğlu L*, Toprak U, Üstüner E, Temel E, Özer H and Mamedova D

Ankara Numune Training and Research Hospital, Altındağ, Ankara, Turkey

*Corresponding Author:
Lale Paşaoğlu
Radiologist, Ankara Numune Training and Research Hospital
Talatpaşa Blv No: 44, Altindag, Ankara, Turkey
Tel: 00905357687688
E-mail: [email protected]

Received date: August 06, 2017; Accepted date: August 16, 2017; Published date: August 21, 2017

Citation: Paşaoğlu L, Toprak U, Üstüner E, Temel E, Özer H, et al. (2017) Are Variations of Paranasal Sinuses and Infundibular Trace Length Responsible for Development of Maxillary Sinusitis? OMICS J Radiol 6:270. doi: 10.4172/2167-7964.1000270

Copyright: © 2017 Paşaoğlu L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Purpose: To determine whether the lenght and width of ethmoid infundibulum relate to maxillary sinusitis. In addition, evaluation of the relationship of maxillary sinusitis to the type of infundibulum and to anatomical sinonasal variations is also aimed to observe.

Materials and methods: Paranasal sinus computerized tomography images of 491 clinically proven rhinosinusitis cases are analyzed retrospectively by two radiologysts. The length is measured by drawing curve traces and width is measured from the narrowest region for 982 ethmoid infundibula in-total. Maxillary sinusitis of the cases is graded according to the Lund and MacKay score. Type, width and length of ethmoid infundibulum and sinonasal anatomical variations are compared for the cases in terms of having with and without maxillary sinusitis.

Results: Type and length of ethmoid infundibulum are found not to be risk factors for maxillary sinusitis (p>0.05). Length of EI are similar between score 0 and score 1-2 maxillary sinusitis (p>0.05) but width was much more in patients with having score 1 and 2 maxillary sinusitis compared with those not having sinusitis (score 0) (p<0.05). Maxillary ostial closure with according expansion of ethmoid infundibulum is seen in maxillary sinusitis. Sinusitis risk is increased in presence of ethmoid bulla. The other anatomical variations can not be determined as risk factors for sinusitis.

Conclusion: In contrary to general belief, paranasal variations do not constitute risk for maxillary sinusitis apart from ethmoid bulla. Type and trace length of infundibulum are not risk factors for sinusitis. Ethmoid infundibulum is expanded with sinusitis.

Keywords

Ethmoid infundibulum; Maxillary sinusitis; Computed tomography

Introduction

The Ostiomeatal Complex (OMC) is a drainage mechanism for maxillary, frontal, anterior and posterior ethmoid cells. The OMC is composed of ethmoid infundibulum, uncinate process, ethmoid bulla, semilunar hiatus and medial meatus. Normal mucociliary drainage is related to ostium opening. Even with open ostium, a breakdown of mucociliary drainage, accumulating mucus and resulting with infection are claimed to occur in the contact of two opposing mucosal surface. Obstruction with mucociliary drainage dysfunction resulting in repeated inflammatory sinonasal diseases is thought to occur. Ethmoid Infundibulum (EI) which forms the main constitution of OMC was found to be wider and shorter than normal in children with acute complicated sinusitis and the uncinate process which forms the medial wall of the EI was found shorter in another study conducted on adults with chronic sinusitis.

The relation between sinonasal anatomical variations and sinonasal infections is not clear. While some researchers have claimed that anatomical variations increase chronic sinusitis risk, other researchers have not found a relation between sinonasal variations and sinusitis. Showing sinonasal anatomical variations before functional endoscopic sinus surgery blocks the possible complications. Computed Tomography (CT) is the preferred imaging modality for demonstrating sinonasal variations and pathologies. In this study, the anatomical variations of the OMC, in particular the length and width of EI are studied in relation to maxillary sinusitis and ostiomeatal disease to detect whether a correlation exists [1-21].

Material and Methods

Local ethics committee approval was obtained. Images of 200 (40.7%) females average age 40.36 ± 13.99 and 291 (59.3%) male with average age of 38 (12-85) totaling 491 cases with clinically proven rhinosinusitis are studied by use of scanning paranasal CT without contrast. Postoperative cases, those having sinonasal polyposis or sinonasal malignancy cases are excluded from the study. Paranasal CT images are acquired from the PACS retrospectively. Scans are performed with 64 slice (Aquilion 64, Toshiba Medical Systems, 2011, Japan) CT device. Scanning parameters in 64 detectors CT were as follows: FOV: 16 cm, collimation 64 × 1, gantry rotation time 0.6 s, slice thickness 1 mm, step value 0.64, 120 kV and 250 mA. Anterior and lateral scanogram are performed after patients lying down in supine position. Scanning in axial plan is realized from frontal sinus roof to mandible. The images are evaluated using Osirix soft ware (7.0, 64 bit, Switzerland). CT images of all the cases are evaluated by two exprienced radiologists. Coronal and sagittal Multiplanar Reconstruction (MPR) images are obtained through axial images. Infundibulum widths are calculated coronal plan images with 950% augmentation from uncinate process to outward contour of orbital medial wall (Figure 1). Infundibulum length is measured coronal plan 3-D curved multiplanar reconstruction imaging with 100% augmentation drawing trace from ostium to semilunar hiatus (Figures 2 and 3). Uncinate process adhering with lamina papyracea is classified as type 1, cribriform plate as type 2, middle concha as type 3 EI (Figures 4-6). Anatomical variations such as Haller cell, uncinate aeration, ethmoid bulla, middle turbinate lamella aeration, bullous middle turbinate, paradoxical middle turbinate, septum deformity are recorded. Maxillary sinusitis is graded according to Lund and MacKay score.

radiology-Ethmoid-infundibulum

Figure 1: Ethmoid infundibulum width is measured from bone to bone in narrowest region (the yellow arrow) on coronal computed tomography Multiplanar Reconstruction Image (MPR).

radiology-infundibulum-trace

Figure 2: Ethmoid infundibulum trace is measured certain length from ostium to semilunar hiatus (dotted red line) on coronal CT image.

radiology-curved-MPR-image

Figure 3: Ethmoid infundibulum trace is flattened after drawing in coronal curved MPR image.

radiology-lamina-papyracea

Figure 4: Type 1 ethmoid infundibulum. Left uncinate process adheres with lamina papyracea (blue arrow) on coronal CT image.

radiology-coronal-CT-image

Figure 5: Type 2 ethmoid infundibulum. Bilateral uncinate processes adhere with cribriform plate (blue arrows) on coronal CT image.

radiology-ethmoid-infundibulum

Figure 6: Type 3 ethmoid infundibulum. Uncinate process adheres with middle concha in left (blue arrow) on coronal CT image.

Score 0: No abnormality.

Score 1: Partial opacification.

Score 2: Total opacification.

Statistical Analysis

One way variance analysis (One way ANOVA) is used to compare between maxillary sinusitis score and EI length, width. Chi square test is used to compare between sinusitis score and nominal variants (sinus type, variations). Score 0 maxillary sinus is grouped as sinusitis is absent. Score 1 and 2 grouped as “sinusitis is present”. T test is used to evaluate the difference between length and width, chi square test is used to compare with nominal variants and sinusitis status (present-absent) for these two groups. Independent variants (sinus type and variations) that can affect sinusitis existence are analyzed by logistic regression analysis. SPSS 11.5 package program is used in analysis and p<0.05 is accepted as statistically significant level.

Results

Average EI length of 982 subjects were 1.33 ± 0.29 (0.45-2.57) (Min-Max) milimeters. Average EI width were 2.01 ± 0.64 (0.58-6.69)) (Min-Max) milimeters. 662 (67.4%) of 982 ethmoid infundibula were Type 1, 139 (14.2%) were Type 2, 181 (18.4%) were type 3. Of all 982 subjects, 294 (29.9%) have score 0, 614 (62,6%) have score 1, and 74 (7, 5 %) have score 2 maxillary sinusitis. Score 0 maxillary sinus subjects were considered as control group. Haller cell was encountered in 864 (88%), aerated uncinate process in 880 (89.6%), ethmoid bulla in 489 (49.8%), bullous middle turbinate in 556 (75.5%), paradoxical middle turbinate in 820 (83.5%).

There was no relation between sinusitis scores and infundibulum length (p>0.05).

Length of EI are similar between scores 0-2 maxillary sinusitis (p>0.05) but width was much more in patients with having score 1 and 2 maxillary sinusitis compared with those not having sinusitis (score 0) (p<0.05) (Table 1).

  Sinusitis present  (N=294) Sinusitis absent (N=688) p
Average  ±  SD Average  ±  SD
EI Length 1.31 ± 0.25 1.33 ± 0.31 0.320
EI Width 1.93 ± 0.56 2.04 ± 0.66 0.006*

Table 1: Relation between sinusitis existence and infundibulum dimensions.

The relation between sinusitis scores, infundibulum type and paranasal variations is summarized in Table 2. A relation between sinusitis scores and infundibulum types is not found (p>0.05). Haller cells are more frequent in score 1 (p<0.05). Sinusitis scores and uncinate aeration are not related to each other (p>0.05).

  Score 0 Score 1 Score 2 p
N % N % N %
Infundibulum  Type
1 184 27.8 428 64.6 50 7.6   0.060
2 52 37.4 78 56.1 9 6.5
3 58 32 108 49.7 15 8.3
Haller Cell
Absent 254 29.4 538 62.3 72 8.3 0.024*
Present 40 33.9 76 64.4 2 1.7
Aerated Uncinate
Absent 263 29.9 547 62.2 70 8 0.498
Present 31 30.4 67 65.7 4 3.9
Ethmoid Bulla
Absent 126 25.8 306 62.6 57 11.7 0.001*
Present 168 34.1 308 62.5 17 3.4
Lamellar Aeration
Absent 157 28.2 348 62.6 51 9.2 0.014
Present 137 32.2 266 62.5 23 5.4
Bullous Concha
Absent 212 28.6 469 63.3 60 8.1 0.077
Present 82 34 145 60.1 14 5.8
Paradoxical Middle Concha
Absent 243 29.6 515 62.8 62 7.6 0.811
Present 51 31.5 99 61.1 12 7.4
Septum Deformity
Absent 74 35.6 111 53.4 23 11.1 0.038*
Present 220 56.9 431 129.9 51 13.1

Table 2: Relation between infundibular type-paranasal variations and sinusitis score.

There is relation between sinusitis score and ethmoidal bulla (p<0.001). Ethmoid bulla is more frequent in score 1 maxillary sinusitis. Middle turbinate lamellar aeration is similar in score 0 and 1-2 patients. Any relation is not detected between sinusitis score and bullous middle concha (p>0.05). There were no significant difference between sinusitis score and paradoxical middle concha frequencies. Score 1 sinusitis is more frequent compared with score 0 and 2 sinusitis in patients with septum deformity (p<0.05). The relation between infundibulum type, paranasal variations and sinusitis scores is shown in Table 3. Ethmoid bulla is more frequent in patients who had score 1-2 sinusitis in comparison with those score 0 maxillary sinuses (p<0.01). Independent variants (infundibulum type, length, variations) that can affect existence of sinusitis are inserted in a logistic regression analysis and risk factors affecting sinusitis existence are analyzed by retrospective elimination method. An end logistic model is generated with statistically significant variants. Ethmoid bulla is found to be an independent risk factor affecting the existance of sinusitis with regard to this model. Sinusitis risk is increased 1.489 fold in patients had ethmoid bulla (Table 4).

  Sinusitis Present (N=294) Sinusitis Absent
(N=688)
p
N % N %
Type of Infundibulum
1 184 27.8 478 72.2 0.063
2 52 37.4 87 62.6
3 58 32 123 68
Haller Cell
Absent 254 29.4 610 70.6 0.314
Present 40 33.9 78 66.1
Aerated Uncinate
Absent 263 29.9 617 70.1 0.916
Present 31 30.4 71 69.6
Ethmoidal Bulla
Absent 126 25.8 363 74.2 0.004*
Present 168 34.1 325 65.9
Lamellar Middle Concha
Absent 157 28.2 399 71.8 0.184
Present 137 32.2 289 67.8
Bullous concha
Absent 212 28.6 529 71.4 0.111
Present 82 34 159 66
Paradoxical Middle Concha
Absent 243 29.6 577 70.4 0.639
Present 51 31.5 111 68.5
Septum Deformity
Absent 74 35.6 134 64.4 0.135
Present 220 56.5 554 143.1

Table 3: Relation between existence of sinusitis and type of infundibulum-paranasal variations.

  Odds ratio 95%  CI p
Without Ethmoidal Bulla 1 - -
With Ethmoidal Bulla 1. 489 1.131 -  1.961 0.005

Table 4: Relation between sinusitis existence and ethmoid bulla.

Discussion and Conclusion

The OMC is comprised of ostium of the frontal sinus, frontal recess, maxillary sinus ostium, ethmoid infundibulum and middle meatus. Ethmoid infundibulum is the air passage connecting the maxillary sinus ostium to the middle meatus. The uncinate process comprises the medial wall. The lateral wall is formed by the lamina papyracea and frontal process of maxilla and the ethmoid bulla form the posterior wall. EI mainly drains the maxillary sinus [4,10]. It is thought that interference with the drainage process causes sinusitis. Whether bony alterations or mucosal pathologies at the OMC cause the obstruction, is a matter of ongoing debate. Study researching the relation between EI length, width and maxillary sinusitis is limited in literature. Thorp et al. [21] report that the infundibulum is shorter and wider in children with acute sinusitis than in healthy children. Also they report that mucosal changes play a role more than bony changes in the ostiomeatal complex for sinusitis pathogenesis. Pruna [16] made 15 different quantitative measures of structures forming the OMC and report the uncinate process length is shorter in patients with sinusitis. Messerklinger [14] reports the anatomical variations of the middle meatus and infundibulum trigger inflammation by narrowing sinus ostia and the disease extends from there to the other related sinuses.

Treatment modalities are also based upon the bony narrowing concept and therefore aim to widen the drainage routes for example by removing the uncinate process. Our study contradicts this while showing EI length measured drawing trace is not a risk factor for maxillary sinusitis. The ostium is found closed in patients with sinusitis. The infundibulum is widened probably due to the mass effect of inflammatory secretion and decreased mucociliary activity.

A lot of anatomical variations are seen in paranasal sinuses. Certain studies claim some anatomical variations cause inflammation and chronic rhinosinusitis by obstructing sinus drainage ways [6,7,17,20]. On the contrary, Kim et al. [9], Lerdlum et al. [11], Stallman et al. [20] and Katia et al. [17] report there is no relation between anatomical variations and rhinosinusitis as well as that local, systemic, environmental factors and intrinsic mucosal disease are more important in chronic rhinosinusitis pathogenesis. In the study any relation between Haller cell and sinusitis is not detected, on the contrary Haller cell is rarer in patients with sinusitis. A statistical relation between Haller cell existence and maxillary sinusitis is not detected by cone beam CT imaging in Mathew et al. [13]. Also, the relation is not detected in some other studies [9,15,19,20]. On the other hand, there is one study claim that Haller cell existence and narrow infundibulum are related to recurrent acute rhinosinusitis [1]. Nasal septum deformity is seen in 90% of population [1,6,17,22]. Orlandi et al reported that type 3 nasal deformity according to Mladina’s classification has the higher frequency among chronic rhinosinusitis patients [23]. In our study, septal deformities are more frequent in score 1 maxillary sinusitis.

Fadda et al. report ethmoid bulla and ethmoid sinusitis are not related to each other [6]. A study claims there is assosiation between a big ethmoid bulla and maxillary sinusitis [18]. A relation between maxillary sinusitis and bullous concha is not statistically significant in some studies [16,17]. In our study ethmoid bulla is more frequent in patients who had score 1-2 sinusitis in comparison with those score 0 maxillary sinuses so there is correlation of maxillary sinusitis and ethmoid bulla. Ethmoid bulla can narrow the EI and cause maxillary sinusitis.

Bullous concha characterized by bullous part of middle concha pneumatization is reported 9-20%. Maxillary and ethmoid sinusitis can be formed because of bullous and deformed middle concha narrowing middle meatus in some studies [18]. Bullous concha and maxillary sinusitis are not related to each other in Smith et al. study with 883 patients [19]. Bullous middle concha paradoxical middle concha and maxillary sinusitis are not related to each other in our study. Also no significant difference is seen between the sinusitis score, bullous middle concha and paradoxical middle concha rates. However septal deformity is found more frequent in score 1 maxillary sinusitis.

There are some limitations in our study. The concurrence of different anatomical variations has not researched. Medial and lateral deviations of uncinate process are not evaluated. We did’nt calculate the volume of EI. EI volume may be more useful for evaluating the relation with the maxillary sinusitis. Before functional endoscopic sinus surgery reporting anatomical variations is necessary. Because existence of these anatomical variations can affect surgical approaches. These are important for preventing possible complications during surgery [12]. Our study declares the researched variations do not increase sinusitis risk except ethmoid bulla. It is thought that even if a long infundibulum tends to be obstructed and causes sinusitis in general, this condition is not important in the case of sufficient mucociliary activity.

Disclosure of Interest

The authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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