alexa Role of Autacoids in the Development of Vulnerability and Resilience in Patients with Posttraumatic Stress Disorder (PTSD) | Open Access Journals
ISSN: 2161-0479
Journal of Autacoids and Hormones
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Role of Autacoids in the Development of Vulnerability and Resilience in Patients with Posttraumatic Stress Disorder (PTSD)

Shankar GS*
Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA,USA
Corresponding Author : Shankar GS
Department of Pharmacy Practice
and Administration,College of Pharmacy
Western University of Health Sciences
Pomona,CA, 91766-1854
Tel: 909- 469-5459
Fax: 909- 469 -5539
E-mail: [email protected]
Received December 15, 2014; Accepted December 18, 2014; Published December 22, 2014
Citation: Shankar GS (2015) Role of Autacoids in the Development of Vulnerability and Resilience in Patients with Posttraumatic Stress Disorder (PTSD). J Autacoids 5:e126. doi: 10.4172/2161-0479.1000e126
Copyright: © 2015 Shankar GS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Visit for more related articles at Journal of Autacoids and Hormones

Editorial
Trauma related studies indicate abnormal regulation of core neurochemicals (autacoids) through various psychobiological mechanisms that affect the vulnerability and resilience of individuals towards PTSD. These autacoids include monoamines, amino acids, peptides, opioid neurotransmitters and gonadal steroids. Same autacoids are found in various brain circuits that regulate as well as integrate stress and fear complexes. In this paper we will examine the role of monoamines, amino acids and peptides and their role in PTSD.
Monoamines
There are three monoamines in the family, including dopamine (DA), norepinephrine (NE) and serotonin (5HT). First two monoamines are catecholamines and serotonin is an indolamine. Role of DA in PTSD is not very clear even though there is evidence that exposure to stress induces mesolimbic dopamine release that may play a major role in the modulation of HPA axis and often may result some of the psychosis and paranoid behavior associated with some PTSD patients. NE is one of the principal mediators. Catecholamine neurons centrally seem to play a very important role in enhancing the levels of vigilance, alertness, selective attention, fear conditioning and cardiovascular stimuli as described elsewhere. This evidence of catecholamine dysregulation increases the vulnerability to PTSD through the mechanisms of increased heart rate and blood pressure when an individual is exposed to visual or auditory trauma. Preventing pre-synaptic NE release with alpha 2 adrenergic agonists (clonidine) or opioids, or blocking post-synaptic norepinephrine with beta adrenergic blockers (propranolol) may diminish the fear conditioning [1].
Serotonin (5HT)
Stored in the raphe nuclei in the brain stem and projects to several areas of the brain including amygdala, hippocampus, PFC, bed nucleus of strain terminalis and hypothalamus. Serotonin has around 16 receptors and 5HT1A plays an important role in anxiety disorders. There is evidence of serotonergic dysregulation in PTSD and my include symptoms of aggression, depression, impulsivity and suicidality and serotonin reuptake inhibitors seem to be efficacious to control these symptoms. Studies on brain serotonin 5HT1A and 5HT1B suggest they potentially and specifically reduce aggressive behavior without motor slowing and sedative effects [2]. Recently research scientists have discovered the effect of low serotonin 1B levels in patients diagnosed with posttraumatic stress disorder [3]. Serotonin, along with associating brain chemicals has been the concentration of research for most of psychological anguish.
Amino acids
Gamma amino benzoic acid (GABA) is an inhibitory neurotransmitter in the brain. GABA has anxiolytic effects and diminishes the physiological effects to stress with its inhibitory response. GABA effects are mediated by GABAa receptors that are associated with benzodiazepine receptors. Benzodiazepine receptors potentiate the effects of GABAa. Pet studies have shown decreased receptor affinity of benzodiazepine receptors may play a role in PTSD and thus increase in vulnerability of the individual [4]. Glutamate on the contrary is the excitory neurotransmitter in the brain. Stress releases glucocorticoids through negative feedback of cortisol production and glucocorticoids activate glutamate release in the brain. Glutamate binds to NMDA receptors in the brain and this NMDA receptor system plays an important central role in the disassociation and derealization and glutamate is excitotoxic and may contribute to the cell loss in hippocampus and PFC in patients with PTSD.
Peptides
Corticotropin-releasing hormone (CRH)
CRH neurons by assimilating the information about stress,function as the major constituent of HPA axis. CRH neurons are found throughout the brain but also in PFC, amygdala including bed nucleus of stria terminalis, raphe nucleus, LC and hippocampus. When amygdalar CRH containing neurons project to LC, that projection may create anxiety like states and increased fear response and startle response. It is known that earlier life stress associated with trauma may maintain higher levels of brain CRH activity and an organism’s response to this increased allostatic load depends upon social situations, length of the stress and behavioral dominance [5]. Persistent high levels of CRH increases allostatic load and this may be implicated in PTSD [6]. Resilience in this situation is related to the ability of the organism to restrict the CRH response to stress. CRH-1 and CRH-2 receptors are found in the PFC, amygdala and hippocampus along with other areas. CRH-1 receptors may be involved in the anxiety like response and CRH-2 may be involved in anxiolytic response. However, these two receptor systems have not been evaluated in living human systems.
Galanin
It is a peptide and comprises 30 amino acids. Galanin performs a vital role in many physiological and psychological tasks. Galanin participates a part in learning, pain control, memory, and neuroendocrinetask and according to recent studies it also plays a role in anxiety response [7]. Majority of the norepinephrine cells in LC codirect Galan in and this system innervates PFC, hippocampus, amygdala and hypothalamus. In response to stress, norepinephrine can recruit the release of galanin in the central nucleus of amygdala and PFC. From there galanin buffers the anxiogenic effects of norepinephrine. The behavior response of stress induced norepinephrine hyperactivity depends upon the balance between galanin, norepinephrine and neuropeptide y neurotransmission and this balance decides the resilience of the individual. This is a novel concept for the development of medications for PTSD or major depression.
Neuropeptide Y (NPY)
It is a 36 amino acid peptide and this is very abundant peptide in mammalian brain. Moderate levels of this peptide are available in PFC, amygdala, and hippocampus. Receptors for NPY are associated with locations in brain that are implicated in stress: amygdala, hippocampus and LC. In amygdala increased levels of NPY are associated with decreased levels and intensity of anxiety [8]. Studies have shown that NPY levels also decrease the rate of LC firing which usually results in the lower level of NE in the brain. This decrease of NE has positive effect in decreasing the damage in the brain to the prolonged stress [9]. NPY besides its effects on NE at LC also has very important interaction with CRH with positive benefits. In some of the most important parts of the brain associated with arousal, CRH and NPY counter-balance each other. NPY in amygdala decreases arousal and decreases anxiety, whereas CRH can promote activation in amygdala and increased feelings of anxiety. In LC, CRH increases the neuronal firing and increases NE levels, whereas, NPY has a balanced effect, resulting decrease in NE levels and firing [8]. In other words, it is important to have balance between CRH and NPY to maintain some sort of homeostasis of the system. CRH maintains system’s response to stress, preparing the individual for the survival and NPY is in need to counterbalance the damages caused by the prolonged stress and deleterious effects of CRH. In other words, deducing from the effects of NPY, we can deduct NPY has counter regulatory effects on both CRH and LC-norepinepinephrine system at those areas in the brain that are cardinal in the expression of anxiety, worry, fear and also depression. This information suggests NPY system plays an important role in the psychobiology of vulnerability and resilience. In fact some studies have pointed out the higher level of performance with extreme training stress among soldiers are associated with high NPY levels. People with PTSD have shown low NPY levels in several studies and antidepressant drugs have shown to increase NPY [10].
Resilience and Vulnerability to Stress
We have examined several autacoids belonging to 3 groups and their psychobiological response to extreme stress and their contribution alone or working with other functional systems to resilience and vulnerability in the expression of PTSD. The concept of allostatic load is very useful as an indicator to observe the changes in individual and decline in functionality caused by allostatic load. It seems like resilience to PTSD is characterized in people with high measures of DHEA, NPY, galanin,5HT1b, benzodiazepine receptor function and vulnerability increase can be observed for CRH, LCnorepinephrine activity, HPA axis. It should be noted there are only mediators discussed in the paper and the list is not exhausted. However we have an understanding about the mediators in the psychobiological system that can increase vulnerability to PTSD and about the mediators that can improve resilience for PTSD. In future the drug therapy will focus on these factors either to decrease the vulnerability or increase resilience to improve the treatment for PTSD.
References










Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 11713
  • [From(publication date):
    May-2015 - Nov 22, 2017]
  • Breakdown by view type
  • HTML page views : 7925
  • PDF downloads : 3788
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords