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Direct Antiglobulin Reactions in Plasmodium falciparum Parasitized Patients in Sokoto, North Western Nigeria | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Research Article

Direct Antiglobulin Reactions in Plasmodium falciparum Parasitized Patients in Sokoto, North Western Nigeria

Uko EK, Erhabor O*, Isaac IZ, Kabiru M, Bello Y, Okwesili AN, Buhari HA, Wase A, Onuigwe F U and Mainasara Y
Department of Haematology and Transfusion Medicine, College of Health Sciences, Faculty of Medical Laboratory Science, Usmanu Danfodio University, Sokoto, Nigeria
Corresponding Author : Dr. Erhabor O
Associate Professor of Haematology and Transfusion Medicine
Department of Haematology and Transfusion Medicine
College of Health Sciences
Faculty of Medical Laboratory Science
Usmanu Danfodio University, Sokoto, Nigeria
Tel: +447932363217
E-mail: [email protected]
Received September 04, 2013; Accepted October 19, 2013; Published October 26, 2013
Citation: Uko EK, Erhabor O, Isaac IZ, Kabiru M, Bello Y, et al. (2013) Direct Antiglobulin Reactions in Plasmodium falciparum Parasitized Patients in Sokoto, North Western Nigeria. J Infect Dis Ther 1:117. doi: 10.4172/2332-0877.1000117
Copyright: © 2013 Uko EK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Background: Malaria is a global public health problem affecting people particularly in tropical and sub-tropical regions of the world. Immune mediated haemolysis is thought to occur in malaria infection. The aim of this study was to investigate the incidence of direct antiglobulin positivity among 100 patients with P. falciparum malaria in Sokoto, North Western Nigeria.

Method: Evidence of immune mediated haemolysis with characteristic positive direct Coombs test was investigated among a cohort of 100 Plasmodium falciparum parasitized subjects aged 6 to 45 years and mean age 26.9 ± 8.25 years, made of 56 males (56%) and 44 females (44%) resident in Sokoto, North Western, Nigeria.

Result: Amongst the 100 subjects with uncomplicated malaria infection, 3 (3%) had a positive Direct Antiglobulin Test (DAT). The incidence of positive DAT was concentrated among subjects in the 6-15 years age groups (p=0.001). There was no gender–related differences in the incidence of positive DAT among the subjects.

Conclusion: These findings indicate that a positive DAT is common in Plasmodium falciparum parasitized Nigerians. Malaria–related positive DAT may be responsible for the anaemia seen in patients with malaria. There is the need for the routine monitoring of malaria parasitized subjects, particularly those with anaemia in the area.


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