Effect of Liver Biotoxins of Certain Marine Fishes on Mouse Cell Culture | OMICS International | Abstract
ISSN: 2155-9910

Journal of Marine Science: Research & Development
Open Access

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Research Article

Effect of Liver Biotoxins of Certain Marine Fishes on Mouse Cell Culture

Yogesh Kumar and Pani Prasad Kurcheti*

Division of Aquatic Environment and Health Management, Central Institute of Fisheries Education, (Deemed University), Mumbai-400 061, India

*Corresponding Author:
Pani Prasad Kurcheti
Division of Aquatic Environment and Health Management
Central Institute of Fisheries Education (Deemed University)
Mumbai-400 061, India
Tel: 0091 9867241101
Fax: +91-22-26361573
E-mail: [email protected]

Received date: December 11, 2012; Accepted date: January 11, 2013; Published date: January 15, 2013

Citation: Kumar Y, Kurcheti PP (2013) Effect of Liver Biotoxins of Certain Marine Fishes on Mouse Cell Culture. J Marine Sci Res Dev 3:117. doi: 10.4172/2155-9910.1000117

Copyright: © 2013 Kumar Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Biotoxins from certain marine fishes are not only harmful to marine animals and their native environment, but also have pharmacological importance, and can be used as medicines. An investigation was carried out to study the effects of liver biotoxins of marine fish (Chelonodon patoca), catfish (Osteogeneiosus militaries), and mackerel (Rastrelliger kanagurta) on mouse, and their established kidney and liver cell lines. Among the three toxins, puffer liver toxin was the most toxic in mouse, with 5 mouse units/ml, followed by 2.5 mouse units/ml and 0.67 mouse units/ml of catfish and mackerel, respectively. The morphological rigidity, viability, swelling and syncitia formation, followed by cell death, are the common features recorded in both cell lines. The Tissue Culture Infective Dose (TCID50) was the highest for puffer liver toxin in both cell lines, followed by catfish and mackerel liver toxin.