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Hindi Research Article
EFFICIENT METHOD FOR ENANTIOSELECTIVE SYNTHESIS OF DEXMETHYLPHENIDATE HYDROCHLORIDE (FOCALIN?)
Abstract
An improved economical and eco friendly process for the enantioselective resolution of methylphenidate free base to give (2R,2’R)-(+)-threomethylphenidate via diastereomeric salt preparation with (+)-di-para-toluyl-D-tartaric acid has been achieved. The racemic resolution performed under mild and neutral conditions having simple unit operation making process feasible for large scale production of dexmethylphenidate hydrochloride
