alexa FORMULATION AND EVALUATION OF IMMEDIATE AND SUSTAINED RELEASE BILAYERED TABLET WITH GLIBENCLAMIDE AND METFORMIN HYDROCHLORIDE
ISSN: 2278-0238

International Journal of Research and Development in Pharmacy & Life Sciences
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

FORMULATION AND EVALUATION OF IMMEDIATE AND SUSTAINED RELEASE BILAYERED TABLET WITH GLIBENCLAMIDE AND METFORMIN HYDROCHLORIDE

 
To read the full article Peer-reviewed Article PDF image

Abstract

The aim of the present research work is to develop bilayer tablet dosage form containing combination of immediate and sustained release layer prepared using Glibenclamide and Metformin Hydrochloride respectively for the treatment of Type-11 diabetes mellitus. Immediate release of glibenclamide granules was prepared with different superdisintegrant. Metformin hydrochloride sustained release granules were prepared by non-aqueous wet granulation technique. Both pre-compression and post compression parameters were analyzed for all the tablets. Bilayer tablets was formulated using croscarmellose sodium for immediate release of Glibenclamide showed 99.94% of release in 30 minutes and using hydrophilic HPMC K100 and hydrophobic Ethyl cellulose in the ratio of 1:1 released 99.90% of Metformin hydrochloride for the period of 13 hours. From this research work it is evident that the formulated bilayer tablet has ability to release the Glibenclamide immediately and Metformin hydrochloride for longer period of time, which can be used for treatment of type11 diabetes mellitus compared to Marketed formulation.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords