In vivo PKPD evaluation and computer modelling of apocynin in reducing organ superoxide production*Corresponding Author:
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Oxidative stress due to the activation of Nox2-NADPH oxidase (Nox2) plays an important role in the pathogenesis of many diseases. Apocynin (4'-hydroxy-3'methoxyacetophenone) is an inhibitor of the Nox2 enzyme widely used in many preclinical and experimental studies. However, its in vivo pharmacokinetics and tissue distribution have not been well evaluated.