Instability in Oncogenesis Directly Implicates Mutator Phenotype Progression through Genetic Lesion Heterogeneity
Lawrence M Agius*
Department of Pathology, Mater Dei Hospital, Tal-Qroqq, University of Malta Medical School, Msida, Malta, Europe
- *Corresponding Author:
- Lawrence M Agius
Department of Pathology, Mater Dei Hospital
Tal-Qroqq, University of Malta Medical School
Msida, Malta, Europe
E-mail: [email protected]
Received date: September 06, 2016; Accepted date: September 21, 2016; Published date: September 26, 2016
Citation: Agius LM (2016) Instability in Oncogenesis Directly Implicates Mutator Phenotype Progression through Genetic Lesion Heterogeneity. Adv Cancer Prev 1:116. doi: 10.4172/2472-0429.1000116
Copyright: © 2016 Agius LM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Theoretical uncertainties regarding the dimensions of mutator mutations are reflected particularly in the parameter uncertainties of the oncogenic pathways that are heterogeneous in individual tumor cells. The key attribute of marked heterogeneity in genomic lesions attests for the essential evolution of the mutator phenotype per se, and allows for the emergence of oncogenesis beyond initial or middle course events in malignant transformation. Although initial or early mutator mutations may prove rare events in oncogenesis, the emergence also of passenger mutations reflect an essential establishment of a mutator phenotype as essential genomic instability and mutability.