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Nausea and Vomiting in Cancer Patients: Topic Review | OMICS International | Abstract
ISSN: 2165-7386

Journal of Palliative Care & Medicine
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Review Article

Nausea and Vomiting in Cancer Patients: Topic Review

Nagwa A.E. Ibrahim*

Department of Pharmaceutical Services, Prince Sultan Military Medical City, Saudi Arabia

*Corresponding Author:
Nagwa A.E. Ibrahim
Department of Pharmaceutical Services
Prince Sultan Military Medical City, Riyadh, Saudi Arabia
Tel: +9664777714

Received date: November 13, 2014; Accepted date: January 8, 2015; Published date: January 20, 2015

Citation: Ibrahim NAE (2015) Nausea and Vomiting in Cancer Patients: Topic Review. J Palliat Care Med 5:203.doi:10.4172/2165-7386.1000203

Copyright: ©2015 Ibrahim NAE. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Nausea and vomiting are known side effects for cancer therapy. The prevalence is around 40-80%. The level of emetoginicity varies based on different factors. The potential receptors involved in emesis pathway are dopamine receptors, 5-hydroxytryptamine type 3 receptors and neurokinin receptors. The main guidelines for prevention of nausea and vomiting are ASCO, NCCN, MASCC/ESMO. These guidelines recommend three antiemetic drugs for highly emetic chemotherapy and two antiemetic drugs for moderately emetic chemotherapy. While for low risk regimens single antiemetic might be used and for minimal risk regimens antiemetic is not routinely recommended. Non pharmacological therapy might be considered as well. There are different tools for assessment of nausea and vomiting such as EORTC-QLQ-C30 and FACT-G. The Multinational Association of Supportive Care in Cancer (MASCC) tool individually address both acute and delayed nausea and vomiting, available in different languages and has iPhone/iPad application. Proper prevention of this side effect is highly recommended to improve patient quality of life, to avoid further complications as dehydration, electrolyte imbalance and to ensure continuation of treatment plan.


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