Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women | OMICS International | Abstract
ISSN: 2161-0711

Journal of Community Medicine & Health Education
Open Access

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Research Article

Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women

Shuman Yang1, Majken K Jensen2,3, Palash Mallick1, Eric B Rimm2,3, Walter C Willett2,3 and Tianying Wu1,*

1Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA

2Departments of Nutrition and Epidemiology, Harvard T.H. Chan, School of Public Health, USA

3The Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

*Corresponding Author:
Tianying Wu
Division of Epidemiology and Biostatistics
Department of Environmental Health
University of Cincinnati Medical Center
Kettering Complex, 3223 Eden Ave, Cincinnati, Ohio, USA, 45267-0056
Tel: 15135566229
Fax: 15135580925
E-mail: [email protected]

Received date: October 12, 2015 Accepted date: October 23, 2015 Published date: October 30, 2015

Citation: Yang S, Jensen MK, Mallick P, Rimm EB, Willett WC, et al. (2015) Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women. J Community Med Health Educ 5:377. doi:10.4172/2161-0711.1000377

Copyright: © 2015 Yang S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objectives: The associations between physical activity and oxidative stress biomarkers are still controversial, and few large human studies have comprehensively investigated the relationship between physical activity and oxidative stress biomarkers. The purpose of this study was to examine the association between physical activity and oxidative stress biomarkers in a large sample of women by measuring biomarkers of both oxidation and antioxidant defense.

Design and Methods: We conducted a cross-sectional study among 1,144 generally healthy women ages 43-70 years, who were included in a prospective nested case-control study of coronary heart disease in the Nurses’ Health Study. Fluorescent oxidation products (FlOPs) are oxidation markers reflecting global oxidation burden. Antioxidant defense was quantified by the activities of three major antioxidant enzymes in erythrocyte (superoxide dismutase [SOD], glutathione peroxidase [GPx] and catalase [CAT]). Self-reported physical activity was estimated in metabolic equivalents per week.

Results: Physical activity was not associated with FlOP levels, or GPx and CAT activities after adjusting for covariates (all Ptrend>0.15). Higher levels of physical activity were associated with decreased SOD activity (Ptrend<0.01). We then conducted subgroup analysis of participants with and without any vigorous physical activity. Greater levels of physical activity were associated with lower SOD activity among participants with any vigorous physical activity (Ptrend=0.02).

Conclusions: Greater physical activity was associated with lower SOD activity, but not with higher plasma FlOPs in generally healthy women. Our findings may be important for women to maintain a low level of oxidative stress during exercise because high oxidative stress is related to the development of many chronic diseases