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Obesity is a Risk Factor for Renal Toxicity and Wound Complications among a Cohort of Pediatric Cancer Patients at a Single Tertiary Care Institution | OMICS International | Abstract
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Obesity is a Risk Factor for Renal Toxicity and Wound Complications among a Cohort of Pediatric Cancer Patients at a Single Tertiary Care Institution

Jennifer H Aldrink1*, Catherine Paris2, Wei Wang3, Erin Teeple4, Aaron Wilcox5, Kasi Eastep1, Sarah H O’Brien6 and Marc P Michalsky1
1Department of Surgery, Division of Pediatric Surgery, Ohio State University College of Medicine, USA
2Department of Surgery, Division of Pediatric Surgery, Sherbrooke University Hospital Center, Canada
3Department of Biostatistics, Nationwide Children’s Hospital, USA
4Department of General Surgery, Brigham and Women’s Hospital, USA
5Department of General Surgery, Mount Carmel Health System, USA
6Department of Pediatrics, Division of Pediatric Hematology/Oncology/Bone Marrow Transplantation, Nationwide Children’s Hospital, USA
Corresponding Author : Jennifer H. Aldrink, M.D., FACS, FAAP
Assistant Professor of Clinical Surgery
Nationwide Children’s Hospital
Division of Pediatric Surgery
700 Children’s Drive, ED320
Columbus, Ohio 43205, USA
Tel: 614-722-0440
Fax: 614-722-3903
E-mail: [email protected]
Received June 20, 2014; Accepted August 21, 2014; Published August 25, 2014
Citation: Aldrink JH, Paris C, Wang W, Teeple E, Wilcox A, et al. (2014) Obesity is a Risk Factor for Renal Toxicity and Wound Complications among a Cohort of Pediatric Cancer Patients at a Single Tertiary Care Institution. J Obes Weight Loss Ther 4:224. doi:10.4172/2165-7904.1000224
Copyright: © 2014 Aldrink JH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Evidence exists in the adult literature linking obesity to an elevated risk for the development of certain malignancies, and to an increase in treatment-related complications. Little information is available examining this relationship in the obese pediatric oncology population. Methods: We performed a retrospective analysis for all patients with a malignancy and treated at our institution between January, 2005 and December, 2009. Body mass index (BMI) was calculated, categorizing them as obese or nonobese based upon their BMI percentile. Stratification by tumor type (leukemia/lymphoma, solid tumor) was performed. Data on the incidence of fifteen potential complications were recorded. Results: Sixty-three patients (17%) were classified as obese, and 302 (83%) as nonobese. Wound complications occurred more frequently in obese patients with leukemia/lymphoma compared to nonobese patients (13.2% vs. 1.6%, p=0.0075). Renal toxicity occurred more frequently in the obese patients than in the nonobese patients (38.1% vs. 26.2% (p=0.06). Conclusions: In a growing population of obese pediatric patients, certain malignancy-related treatment complications may occur at an increased incidence, including higher rates of renal toxicity and wound complications. This report highlights early treatment-related complications by BMI in pediatric patients with cancer, and demonstrates the need for an individualized approach in treating this population.


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