ISSN: 2155-9910

Journal of Marine Science: Research & Development
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Opinion Article

Probing Potent Interfacial Residues in Microvirin before Complexation with Glycoproteins: Visualizing Anti-HIV Activity in silico

Paramasivan Manivannan and Gangatharan Muralitharan*

Department of Microbiology, Bharathidasan University, Tiruchirappalli, India

Corresponding Author:
Gangatharan Muralitharan
Department of Microbiology
Bharathidasan University
Tiruchirappalli, Tamilnadu, India
Tel: +91 431 2407082
E-mail: drgm@bdu.ac.in

Received Date: March 02, 2016; Accepted Date: October 04, 2017; Published Date: October 06, 2017

Citation: Manivannan P, Muralitharan G (2017) Probing Potent Interfacial Residues in Microvirin before Complexation with Glycoproteins: Visualizing Anti-HIV Activity in silico. J Marine Sci Res Dev 7:241. doi:10.4172/2155-9910.1000241

Copyright: © 2017 Manivannan P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Microvirin, a mannose binding anti-HIV (Human Immunodeficiency virus) lectin has been proved as a potent agent in combating HIV. Ligand binding residues of Microvirin was taken in to account for analysis of interfacial residues and identify surface/Buried residues based on Accessible surface area and free energy based calculations. After categorization, Comparative B factors were assessed for prediction of Rigid/Non-Rigid residues among the Ligand binding residues. Furthermore docking microvirin with glycoproteins gp120 and gp41 revealed the conserved interfacial residues in complexes and affirms the computational dissection of microvirin’s anti-HIV activity.

Keywords

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Citations : 3189

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