alexa Stem Cell Approaches for Treatment of Neurodegenerative
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

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Review Article

Stem Cell Approaches for Treatment of Neurodegenerative Diseases

Saurabh Anand and Kiminobu Sugaya*
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, USA
Corresponding Author : Kiminobu Sugaya
Burnett School of Biomedical Sciences
College of Medicine, University of Central Florida
Orlando, FL 32827, USA
Tel: 407.266.7045
E-mail: [email protected]
Received October 17, 2014; Accepted November 13, 2014; Published November 17, 2014
Citation: Anand S, Sugaya K (2014) Stem Cell Approaches for Treatment of Neurodegenerative Diseases. Clin Pharmacol Biopharm 3:126. doi:10.4172/2167-065X.1000126
Copyright: © 2014 Anand S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Neurodegenerative diseases are devastating age-related disorders severely affecting the patient, caregivers, and enormously increasing the financial burden of the nation. Despite decades of hard work both in laboratory and clinic, the effective treatment specifically designed for a patient is still far from reach. Stem cell therapy, though with several challenges including limited differentiation potential of adult stem cells, ethical issues with using embryonic and fetal stem cells, tumor formation upon transplantation of cells, etc., offers enormous potential for treatment of several neurodegenerative diseases. Pharmacological drugs currently available in the market on the other hand are mainly for alleviating the symptoms and not for treating the disease per se. The efficiency of drug delivery across the bloodbrain barrier, stability, efficacy, and side effects these drugs show on patients are some of the hurdles pharmacological approach has to overcome. A detailed understanding of these complicated diseases at molecular level followed by the right combination of specifically tailored stem cell therapy and/or effective drugs e.g. MS-818 used to increase the endogenous stem cell population might be the best course of action in coming years for patients with little time left after their diagnosis.

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