Vibrational and NMR Investigation on Pharmaceutical Activity of 2,5- Dimethoxy-4-Ethylamphetamine by Theoretical and Experimental SupportA Madanagopal1, S Periandy2, P Gayathri1, S Ramalingam3* and S Xavier4
- Corresponding Author:
- S Ramalingam
PG and Research Department of Physics
A.V.C. College, Mayiladuthurai, Tamilnadu, India
Tel: 04364 222264
Fax: 04364 222264
E-mail: [email protected]
Received Date: January 31, 2017; Accepted Date: February 28, 2017; Published Date: March 07, 2017
Citation: Madanagopal A, Periandy S, Gayathri P, Ramalingam S, Xavier S (2017) Vibrational and NMR Investigation on Pharmaceutical Activity of 2,5-Dimethoxy-4-Ethylamphetamine by Theoretical and Experimental Support. J Mol Pharm Org Process Res 5:135. doi: 10.4172/2329-9053.1000135
Copyright: © 2017 Madanagopal A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Detailed physical, chemical, thermal and circular vibrational investigations have been made on FT-IR, FTRaman, NMR and UV-Visible spectra of 2,5-Dimethoxy-4-ethylamphetamine. The modification of the basic property (deficit hyperactivity disorder) of the base compound (Amphetamine) is favoured by the insertion of two methoxy and ethyl-methyl groups have been discussed in detail. The transitional pattern among NBO emphasized the inducement of the psychedelic activity in the compound. The strong interpretation made on the physical and chemical properties by intense observation using excitations between the electronic energy levels within the molecule have been carried out. The arrangement of the dipole moment of the bonds and the change of resultant magnetic moment were observed from the average Polarizability first order diagonal hyperpolarizability. The receptor and inhibition property of the molecule were interpreted by the identification of reactive sites from molecular electrostatic potential contour map. The chemical reaction continuity is keenly observed from thermodynamical analysis.