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Research Article Open Access
The diagnosis and treatment of heart failure remains meagre even with therapeutic progression in recent times. The possibility of cardiac transplantation is of great risk and restricted by a dearth of donors. Earlier heart was considered to be a terminally differentiated organ inept to regenerate. However, several preclinical and clinical studies have demonstrated that heart could revive to normal function following cell therapy. Over years, investigators have looked at the potential and usage of several kinds of stem cells, which could radically improve the understanding of the regenerative capacity of the heart. Stem cell-related cardiomyocytes regeneration strategies have shown that cell based therapies can mend cardiac function and the repercussions of this are triggering great anticipation. We discuss here current knowledge and status of regenerating adult mammalian heart by stem cell therapy. We also consider the various stem cell and progenitor-cell types that might regenerate the myocardium and review the major clinical trials of them.
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Author(s): Verma V, Yadav CB, Tabassum N, Kumar M, Singh MP, Singh AK, Kumar A, Singh B and Gautam SK
Cardiac stem cell therapy, Pluripotent Stem cells, Cardiomyocytes, Cardiovascular disease, Cell Biology Junctions, Cell Biology Techniques, Cell Cycle