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Dr. Y. Peng Loh is the head of the Section on Cellular Neurobiology, Program on Developmental Neuroscience, NICHD. She and her group studies the cell biology of endocrine and neuroendocrine cells, focusing on the mechanisms of biosynthesis and intracellular trafficking of peptide hormones and neuropeptides and their processing enzymes, the regulation of dense-core secretory granule biogenesis, and the physiological roles of the prohormone processing enzyme carboxypeptidase E, and peptides derived from the neuroendocrine protein , chromogranin A. Her studies have elucidated molecular mechanisms governing protein trafficking to the regulated secretory pathway and identified players and mechanisms that control secretory granule biogenesis and transport in endocrine and neuroendocrine cells and neurons. Her research has also provided a better understanding of diseases such as diabetes, obesity and neurodegeneration. Recently, she and her team have discovered a splice isoform of the enzyme, carboxypeptidase E (CPE-ΔN) that is highly expressed in different types of metastatic tumor cells and is an inducer of tumor growth and metastasis. Clinical studies so far have shown that CPE-âN is a very promising powerful biomarker for predicting future metastasis, and a potential therapeutic target for different malignant cancers.
Research Article: Clin Pharmacol Biopharm 2013, S1: 002
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