Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 2154

Journal of Biotechnology & Biomaterials received 2154 citations as per Google Scholar report

Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Access to Global Online Research in Agriculture (AGORA)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • ICMJE
Recommended Journals
Share This Page

Saroj Hole

 Assistant professor of modern college, Pune University, Maharashtra, India

Biography

Dr. Saroj Hole currently working as a Assistant Professor at the University of Pune, India. 

With interest in DNA damage and repair, initially we worked with islet cells of mouse and human pancreas and showed that they have very poor ability to repair oxidatively damaged DNA compared to liver cells. We developed monoclonal antibody against 8-OH-dG to quantitate the damage in the DNAin collaboration with National Center for Cell Science, Pune.
 
Later on, in collaboration with Dr. Surendra Ghaskadbi’s lab at Agharkar Research Institute, Pune, , we have been working on DNA repair systems in Hydra, a cnidarian. Hydra is a simple diploblastic animal that has been around for over 500million years. It exhibits lack of organismal ageing and a spectacular ability to regenerate. Very little is known about DNA repair in hydra. We have identified a few genes in nucleotide excision repair, base excision repair and are currently characterising them.
 
We are interested in understanding how cells cope up with oxidative stress. We use different cell systems including islet cells, liver cells, muscle cells and adipose cells in this work. Islet cells are insulin producing cells while liver, muscle and adipose cells are insulin responsive cells.We have clearly demonstrated that due to low antioxidant defence, islet cells succumb very easily to oxidative stress leading to impairment of their function of insulin secretion compared to the more robust liver cells. We also showed that treatment with strong antioxidants helps islet cells cope up better with oxidative stress both in vitro and in vivo. We are now trying to understand involvement of oxidative stress in development of insulin resistance in liver, muscle and adipose cells which are insulin responsive.
 
We have recently studied comprehensive oxidative stress profile of newly diagnosed diabetic patients and checked whether this profile improves on controlling hyperglycemia. Our results clearly demonstrate that reduction in glycemic stress in diabetic patients alleviates oxidative stress, improves beta cell function and reduces insulin resistance. Systematic monitoring of oxidative stress with glucose could identify an individual’s recovery trajectory.  In collaboration with Dr. Pranay Goel, Indian Institute of Science Education and Research, Pune, we developed a mathematical model which showed that recovery is marked with a quantal response. From the model we could predict amount of maximal glutathione at low stress, glucose threshold for half-maximal glutathione and  rate at which recovery progresses. We did find significant differences among individuals in their response to glucose control. We believe that this method can help in personalisation of effective target of glucose control in anti-diabetic therapy.
Research Interest

 ATP; Portable; Bioluminescence sensor system; Trichloroacetic acid; Luminescence intensity; biotechnology

Publications

Global Speakers in the subject

Global Experts in the subject

Top