Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us +44-330-822-4832


Is there a Role for IV Dexamethasone in Perioperative Pain Management? | OMICS International
ISSN: 2167-0846
Journal of Pain & Relief
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business

Is there a Role for IV Dexamethasone in Perioperative Pain Management?

Alimorad G Djalali*
Director of Abdominal Surgery Rotation, Department of Anesthesiology, Stanford University, USA
Corresponding Author : Alimorad G Djalali
Assistant Professor
Director of Abdominal Surgery Rotation
Department of Anesthesiology
300 Pasteur Dr, Rm H3580 MC 5640
Stanford, CA 94305, Stanford University, USA
Received August 05, 2012; Accepted August 06, 2012; Published August 08, 2012
Citation: Djalali AG (2012) Is there a Role for IV Dexamethasone in Perioperative Pain Management? J Pain Relief 1:e113. doi: 10.4172/2167-0846.1000e113
Copyright: © 2012 Djalali AG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Pain & Relief

More than twelve years after the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) declared freedom from pain as a quasi human right, treatment of postoperative pain is still a major challenge for providers caring for surgical patients [1].
Patient’s hospital experiences are strongly influenced by their perception of pain management and their provider’s competency to ease pain [2].
In spite of numerous publications “demonizing” the adverse effects of opioids, opioids deservedly remain the major pain treatment modality in our daily anesthesia practice [3]. We must admit that a true alternative to opioids is not yet found. A multimodal approach to the treatment of pain is the current and preferred concept of acute and chronic pain management. By combining opioids with other nonopioid adjuncts, such as gabapentin, pregabalin, ketamine, clonidine, etc., providers seek to reduce the opioid dose by utilizing the additive or synergistic effect of non-opioid substances [4,5].
Following the trend in the literature, a single, IV dose of dexamethasone can be added to the list of adjuncts for pain treatment.
Dexamethasone is a potent steroid with a safe record of side effects [6]. It is best known intraoperatively as an anti-inflammatory agent that reduces tissue edema due to surgical trauma, and as a proven antiemetic. Dexamethasone’s antiemetic property is well-established. The mechanism of action is probably due to reduction of circulating inflammatory mediators that can stimulate the chemoreceptor trigger zone in brain. In addition, the antagonistic effect of dexamethasone on 5-HT receptors may explain its antiemetic capability [7,8]. Yet, the exact antiemetic mechanism of action remains elusive.
A single dose of dexamethasone has been shown to shorten recovery time from surgical procedures and reduce postoperative pain scores [9,10]. These lower scores can be explained by the fact that dexamethasone suppresses prostaglandin production and reduces postoperative tissue edema [11]. Exactly how dexamethasone reduces postoperative pain is based on assumptions that have not been thoroughly elaborated. Nevertheless, a recent meta-analysis underscored the effectiveness of single-dose dexamethasone for postoperative pain control as an adjunct to other pain medications [12].
There is an ongoing debate about the degree to which steroids, including dexamethasone, have adverse effects on patients undergoing major surgeries. One concerning effect is increased risk of surgical wound infection because steroids directly suppress the immune response and elevate a patient’s glucose level. Other rare but possible adverse effects are gastric ulceration and suppression of adrenal gland activity. Also the time of administration matters. Dexamethasone was found to reduce postoperative pain more effectively when given at least an hour prior to surgery or prior to anesthesia induction [14].
In summary, 8 mg of dexamethasone, given shortly prior to surgery is a safe, effective, and inexpensive choice to reduce post-operative pain and (PONV) in lieu of the available data. In patients with uncontrolled diabetes, adrenal gland disorders and other endocrinopathies, dexamethasone should be used judiciously.
Further studies are necessary to establish the minimum effective dose of dexamethasone and the best timing for its application in perioperative setting.


Post your comment

Share This Article

Article Usage

  • Total views: 13505
  • [From(publication date):
    October-2012 - Jul 14, 2024]
  • Breakdown by view type
  • HTML page views : 9052
  • PDF downloads : 4453